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Delivering highly accurate long reads to drive discovery in life science

What is SMRT Sequencing?

Single Molecule, Real-Time (SMRT) Sequencing is the core technology powering our long-read sequencing platforms. This innovative approach was the first of its kind and is now a proven technology used in all fields of life science. Explore each of the SMRT Sequencing Advantages below.

 

 

Long Reads

With reads tens of kilobases in length you can readily assemble complete genomes and sequence full-length transcripts.

Explore the benefits of long reads


High Accuracy

Sequencing free of systematic error achieves >99.999% consensus accuracy.

Learn more about high accuracy


Uniform Coverage

No bias based on GC content means you can sequence through region inaccessible to other technologies.

Discover how uniform coverage lets you see more


Single-Molecule Resolution

Capturing sequence data from native DNA or RNA molecules enables highly accurate long reads with >99% single-molecule accuracy.

See the difference single-molecule resolution makes


Epigenetics

With no PCR amplification step, base modifications are directly detected during sequencing.

Get more from your sequencing with epigenetics


The 2019 HiFi for All SMRT Grant Program is Now Open!

Sequence All Life with Confidence Using HiFi Reads

Tell us how highly accurate long reads (HiFi reads) will drive new discoveries in your research for a chance to win free sequencing.

Learn More

How Does SMRT Sequencing Work?

SMRT Sequencing enables simultaneous collection of data from millions of wells using the natural process of DNA replication to sequence long fragments of native DNA or RNA.

Learn how to go from sample to sequence with this infographic.

 

Original Publication: Eid, J., et al. (2009). Real-time DNA sequencing from single polymerase molecules. Science, 323(5910), 133–138.

 


 

What Can You Do With SMRT Sequencing?

Explore the full range of SMRT Sequencing applications.

Whole Genome Sequencing

For humans, plants, animals and microbes including de novo assembly and variant detection

Complex Populations

Understand variants among bacterial, viral and cancer cell populations

 

RNA Sequencing

In-depth analysis of cDNA sequences across the entire transcriptome or targeted genes

Epigenetics

Detect DNA modifications in your samples while you sequence on the PacBio platform

Targeted Sequencing

Study relevant genome targets across any regions of interest

 


 

Where Can You Get Started with SMRT Sequencing?

 

Learn more about the Sequel II System

Contact a PacBio Certified Service Provider

 

 

 

 


Have Questions about SMRT Sequencing?

 

Connect with a PacBio Scientist:

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