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Authors: Fettweis, Jennifer M and Serrano, Myrna G and Brooks, J Paul and Edwards, David J and Girerd, Philippe H and Parikh, Hardik I and Huang, Bernice and Arodz, Tom J and Edupuganti, Laahirie and Glascock, Abigail L and Xu, Jie and Jimenez, Nicole R and Vivadelli, Stephany C and Fong, Stephen S and Sheth, Nihar U and Jean, Sophonie and Lee, Vladimir and Bokhari, Yahya A and Lara, Ana M and Mistry, Shreni D and Duckworth, Robert A and Bradley, Steven P and Koparde, Vishal N and Orenda, X Valentine and Milton, Sarah H and Rozycki, Sarah K and Matveyev, Andrey V and Wright, Michelle L and Huzurbazar, Snehalata V and Jackson, Eugenie M and Smirnova, Ekaterina and Korlach, Jonas and Tsai, Yu-Chih and Dickinson, Molly R and Brooks, Jamie L and Drake, Jennifer I and Chaffin, Donald O and Sexton, Amber L and Gravett, Michael G and Rubens, Craig E and Wijesooriya, N Romesh and Hendricks-Muñoz, Karen D and Jefferson, Kimberly K and Strauss, Jerome F and Buck, Gregory A

The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency of preterm birth among populations within countries, and women of African ancestry disproportionately bear the burden of risk in the United States. In the present study, we report a community resource that includes 'omics' data from approximately 12,000 samples as part of the integrative Human Microbiome Project. Longitudinal analyses of 16S ribosomal RNA, metagenomic, metatranscriptomic and cytokine profiles from 45 preterm and 90 term birth controls identified harbingers of preterm birth in this cohort of women predominantly of African ancestry. Women who delivered preterm exhibited significantly lower vaginal levels of Lactobacillus crispatus and higher levels of BVAB1, Sneathia amnii, TM7-H1, a group of Prevotella species and nine additional taxa. The first representative genomes of BVAB1 and TM7-H1 are described. Preterm-birth-associated taxa were correlated with proinflammatory cytokines in vaginal fluid. These findings highlight new opportunities for assessment of the risk of preterm birth.

Journal: Nature medicine
DOI: 10.1038/s41591-019-0450-2
Year: 2019

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