Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454.

Authors: Bo, Sheng Tao and Xu, Zi Fei and Yang, Li and Cheng, Ping and Tan, Ren Xiang and Jiao, Rui Hua and Ge, Hui Ming

Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.

Journal: The Journal of antibiotics
DOI: 10.1038/s41429-018-0039-x
Year: 2018

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