September 22, 2019  |  

Plasmid-encoded transferable mecB-mediated methicillin resistance in Staphylococcus aureus.

Authors: Becker, Karsten and van Alen, Sarah and Idelevich, Evgeny A and Schleimer, Nina and Seggewiß, Jochen and Mellmann, Alexander and Kaspar, Ursula and Peters, Georg

During cefoxitin-based nasal screening, phenotypically categorized methicillin-resistant Staphylococcus aureus (MRSA) was isolated and tested negative for the presence of the mecA and mecC genes as well as for the SCCmec-orfX junction region. The isolate was found to carry a mecB gene previously described for Macrococcus caseolyticus but not for staphylococcal species. The gene is flanked by ß-lactam regulatory genes similar to mecR, mecI, and blaZ and is part of an 84.6-kb multidrug-resistance plasmid that harbors genes encoding additional resistances to aminoglycosides (aacA-aphD, aphA, and aadK) as well as macrolides (ermB) and tetracyclines (tetS). This further plasmidborne ß-lactam resistance mechanism harbors the putative risk of acceleration or reacceleration of MRSA spread, resulting in broad ineffectiveness of ß-lactams as a main therapeutic application against staphylococcal infections.

Journal: Emerging infectious diseases
DOI: 10.3201/eid2402.171074
Year: 2018

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