July 7, 2019  |  

MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads.

Authors: Xiao, Chuan-Le and Chen, Ying and Xie, Shang-Qian and Chen, Kai-Ning and Wang, Yan and Han, Yue and Luo, Feng and Xie, Zhi

We present a tool that combines fast mapping, error correction, and de novo assembly (MECAT; accessible at https://github.com/xiaochuanle/MECAT) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or de novo assembly of large genomes using SMS reads on a single computer.

Journal: Nature methods
DOI: 10.1038/nmeth.4432
Year: 2017

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