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Authors: Matthews, Benjamin J and Dudchenko, Olga and Kingan, Sarah B and Koren, Sergey and Antoshechkin, Igor and Crawford, Jacob E and Glassford, William J and Herre, Margaret and Redmond, Seth N and Rose, Noah H and Weedall, Gareth D and Wu, Yang and Batra, Sanjit S and Brito-Sierra, Carlos A and Buckingham, Steven D and Campbell, Corey L and Chan, Saki and Cox, Eric and Evans, Benjamin R and Fansiri, Thanyalak and Filipovic, Igor and Fontaine, Albin and Gloria-Soria, Andrea and Hall, Richard and Joardar, Vinita S and Jones, Andrew K and Kay, Raissa G G and Kodali, Vamsi K and Lee, Joyce and Lycett, Gareth J and Mitchell, Sara N and Muehling, Jill and Murphy, Michael R and Omer, Arina D and Partridge, Frederick A and Peluso, Paul and Aiden, Aviva Presser and Ramasamy, Vidya and Rašic, Gordana and Roy, Sourav and Saavedra-Rodriguez, Karla and Sharan, Shruti and Sharma, Atashi and Smith, Melissa Laird and Turner, Joe and Weakley, Allison M and Zhao, Zhilei and Akbari, Omar S and Black, William C and Cao, Han and Darby, Alistair C and Hill, Catherine A and Johnston, J Spencer and Murphy, Terence D and Raikhel, Alexander S and Sattelle, David B and Sharakhov, Igor V and White, Bradley J and Zhao, Li and Aiden, Erez Lieberman and Mann, Richard S and Lambrechts, Louis and Powell, Jeffrey R and Sharakhova, Maria V and Tu, Zhijian and Robertson, Hugh M and McBride, Carolyn S and Hastie, Alex R and Korlach, Jonas and Neafsey, Daniel E and Phillippy, Adam M and Vosshall, Leslie B

Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.

Journal: Nature
DOI: 10.1038/s41586-018-0692-z
Year: 2018

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