July 7, 2019  |  

Genome evolution to penicillin resistance in serotype 3 Streptococcus pneumoniae by capsular switching.

Authors: Chiba, Naoko and Murayama, Somay Y and Morozumi, Miyuki and Iwata, Satoshi and Ubukata, Kimiko

Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease (n= 124) throughout Japan between April 2010 and March 2013. A penicillin-resistantS. pneumoniae(PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with thecpslocus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3. Copyright © 2017 American Society for Microbiology.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.00478-17
Year: 2017

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