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Authors: Akter, Arzuba and Ooka, Tadasuke and Gotoh, Yasuhiro and Yamamoto, Seigo and Fujita, Hiromi and Terasoma, Fumio and Kida, Kouji and Taira, Masakatsu and Nakadouzono, Fumiko and Gokuden, Mutsuyo and Hirano, Manabu and Miyashiro, Mamoru and Inari, Kouichi and Shimazu, Yukie and Tabara, Kenji and Toyoda, Atsushi and Yoshimura, Dai and Itoh, Takehiko and Kitano, Tomokazu and Sato, Mitsuhiko P and Katsura, Keisuke and Mondal, Shakhinur Islam and Ogura, Yoshitoshi and Ando, Shuji and Hayashi, Tetsuya

Rickettsiae are obligate intracellular bacteria that have small genomes as a result of reductive evolution. Many Rickettsia species of the spotted fever group (SFG) cause tick-borne diseases known as "spotted fevers". The life cycle of SFG rickettsiae is closely associated with that of the tick, which is generally thought to act as a bacterial vector and reservoir that maintains the bacterium through transstadial and transovarial transmission. Each SFG member is thought to have adapted to a specific tick species, thus restricting the bacterial distribution to a relatively limited geographic region. These unique features of SFG rickettsiae allow investigation of how the genomes of such biologically and ecologically specialized bacteria evolve after genome reduction and the types of population structures that are generated. Here, we performed a nationwide, high-resolution phylogenetic analysis of Rickettsia japonica, an etiological agent of Japanese spotted fever that is distributed in Japan and Korea. The comparison of complete or nearly complete sequences obtained from 31 R. japonica strains isolated from various sources in Japan over the past 30 years demonstrated an extremely low level of genomic diversity. In particular, only 34 single nucleotide polymorphisms were identified among the 27 strains of the major lineage containing all clinical isolates and tick isolates from the three tick species. Our data provide novel insights into the biology and genome evolution of R. japonica, including the possibilities of recent clonal expansion and a long generation time in nature due to the long dormant phase associated with tick life cycles.© The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Journal: Genome biology and evolution
DOI: 10.1093/gbe/evw304
Year: 2017

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