September 22, 2019  |  

Emergence of an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A by capsular switching.

Authors: Yang Baek, Jin and Kim, So Hyun and Kang, Cheol-In and Chung, Doo Ryeon and Peck, Kyong Ran and Song, Jae-Hoon and Ko, Kwan Soo

Recently, we have identified an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A isolate from a patient with bacterial meningitis. It belonged to sequence type 8279 (ST8279), a clone identified as XDR serotype 11A isolated in South Korea. We obtained and compared the genome sequences of an XDR 15A and an XDR 11A isolate. The genomes of two XDR isolates were highly identical, except for the capsular polysaccharide (cps) locus and another small region. Capsular switching from 11A to 15A may have occurred via recombination of the cps locus. The emergence of a new XDR clone via capsular switching would be a great concern for public health and in clinical settings. Copyright © 2018 Elsevier GmbH. All rights reserved.

Journal: International journal of medical microbiology
DOI: 10.1016/j.ijmm.2018.08.004
Year: 2018

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