Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli ST131.

Authors: Stoesser, Nicole and Sheppard, Anna E and Peirano, Gisele and Sebra, Robert and Lynch, Tarah and Anson, Luke and Kasarskis, Andrew and Motyl, Mary R and Crook, Derrick W and Pitout, Johann D

OXA-48-like enzymes have emerged as important extended-spectrum ß-lactamases/carbapenemases in E. coli ST131. We report the structure of the first fully sequenced blaOXA-163 plasmid, and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with inter-species/inter-lineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Journal: Antimicrobial agents and chemotherapy
DOI: 10.1128/AAC.01130-16
Year: 2016

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