Coexistence of mcr-1, blaKPC-2 and two copies of fosA3 in a clinical Escherichia coli strain isolated from urine.

Authors: Zhao, Dongdong and Zhou, Zhihui and Hua, Xiaoting and Zhang, Huichuan and Quan, Jingjing and Li, Xi and Yu, Yunsong

Here we report the first clinical Escherichia coli isolate co-harboring mcr-1, blaKPC-2 and two copies of fosA3 from China. The five plasmids of the isolate were completely sequenced and analyzed. Gene mcr-1 and blaKPC-2 were located on IncI2 and IncR plasmid, respectively. A variety of other resistance determinants such as fosA3 (two copies), blaCTX-M-123, blaOXA-1 and blaCTX-M-65 were also identified from the rest plasmids. Copyright © 2018 Elsevier B.V. All rights reserved.

Journal: Infection, genetics and evolution
DOI: 10.1016/j.meegid.2018.02.025
Year: 2018

Read publication