Blog
January 23, 2014
PacBio Service Provider DNA Link Sees Soaring Global Demand for SMRT Sequencing
Since its founding in 2000, the service provider team at Korea-based DNA Link has sought to differentiate itself from other facilities by being an early adopter of new technologies. The…
January 21, 2014
Genome Research Paper: Resolve Complex Genomic Regions for a ‘Fraction of the Cost’ With SMRT Sequencing
A new Genome Research paper describes the application of Single Molecule, Real-Time (SMRT®) Sequencing to resolve repeat-heavy genomic regions in important reference genomes such as human and chimpanzee. In the…
January 16, 2014
Looking Ahead: The 2014 PacBio Technology Roadmap
By Jonas Korlach, Chief Scientific Officer 2013 was an eventful and exciting year for PacBio. As I described in the 2013 roadmap post a year ago, we have applied numerous…
January 13, 2014
Data Release: Preliminary de novo Haploid and Diploid Assemblies of Drosophila melanogaster
Model organisms such as yeast, Arabidopsis and Drosophila have been essential to progress in genetic and biomedical research for more than 100 years. Model organisms are the best, fastest, most…
January 8, 2014
SMRT Sequencing for Plant and Animal Genomes: Learn More at PAG 2014
Many recent studies have demonstrated the use of Single Molecule, Real-Time (SMRT®) Sequencing for larger genomes, from complete reference genomes to de novo discovery of transcript isoforms. These advances include…
December 27, 2013
Breakpoint Detection in Cancer Structural Variants with PacBio May Yield Patient-Specific Data
A new publication from scientists at the University of California, San Diego, demonstrates the use of Single Molecule, Real-Time (SMRT®) Sequencing to identify structural variation (SV) breakpoints in cancer. “Amplification…
December 9, 2013
New Publication Characterizes the Complex Methylomes of Helicobacter pylori
A new paper in Nucleic Acids Research describes the genome-wide methylation state of two strains of Helicobacter pylori, using Single Molecule, Real-Time (SMRT®) Sequencing. The paper represents the first comprehensive…
December 4, 2013
In RNA-seq Study, Long PacBio Reads Allow for Detection of Full-Length and Novel Isoforms
A new paper out in PNAS details the usefulness of long reads for isoform sequencing. “Characterization of the human ESC transcriptome by hybrid sequencing” comes from lead author Kin Fai…
December 3, 2013
PacBio Partners with Sanger Institute and Public Health England to Finish 3,000 Bacterial Genomes
Sanger’s Genome Campus We are pleased to announce a new collaboration with the Wellcome Trust Sanger Institute and Public Health England to complete the sequences of 3,000 bacterial genome strains…
November 20, 2013
New Publication Demonstrates Long-Read Sequences Needed to Thoroughly Resolve Short Tandem Repeats
In a new paper reporting a protocol for using short-read sequence data to locate short tandem repeats (STRs), scientists find that long-read sequence information is necessary to resolve regions with…
November 14, 2013
ASHG Workshop Recordings: Resolving Structural Variation in Human Genomes
We hosted a structural varation workshop at the annual meeting of the American Society of Human Genetics, and were pleased to see that the speakers’ presentations really resonated with attendees…
November 7, 2013
Event Recap: Fall User Group Meeting Presentations & Review
In September we were excited to have 100+ customers gather in Palo Alto, Calif., to discuss their use of Single Molecule, Real-Time (SMRT®) Sequencing and hear about what’s next for…
November 6, 2013
At Institute for Genome Sciences, Long Reads Offer New Path to Finished Genomes
The Genomics Resource Center (GRC) at the Institute for Genome Sciences (IGS) has a scientific pedigree and a sample-to-interpretation service commitment that place it in a league of its own….
November 4, 2013
Comparative Transcriptome Analysis: Insights from a Single SMRT Cell
In a new paper published in the journal Gene, scientists from Rutgers University and King’s College London report the use of a single SMRT® Cell to sequence and assemble more…
October 22, 2013
Data Release: Long-Read Shotgun Sequencing of a Human Genome
In order to help evaluate the utility of long, unbiased sequence reads for characterizing structural variation in the human genome using our recently released P5-C3 scaffolding sequencing chemistry, we have…