Blog
August 22, 2013
The Value of Finished Bacterial Genomes: A Microbiology Primer
Microbiologists have been at the forefront of genomics since Haemophilus influenzae became the first organism to have its full genome sequenced in 1995 using Sanger sequencing. Even with modern technology,…
August 21, 2013
New DNA Polymerase P4 Delivers Higher-Quality Assemblies Using Fewer SMRT Cells
Pacific Biosciences is pleased to announce the introduction of DNA/Polymerase Binding Kit P4. This P4 enzyme has average read lengths of >4,300 bp when paired with the C2 sequencing chemistry…
August 19, 2013
Scientists Assess Error Modes in Sequencing Platforms and Find SMRT Sequencing ‘Least Biased’
A paper from scientists at the Broad Institute reports a rigorous study of bias across all major sequencing platforms. In “Characterizing and measuring bias in sequence data,” published in Genome…
August 1, 2013
#SMRTSeq Tweet Chat: Users Weigh in on Current Applications and Future Outlook for PacBio Sequencing
Today offered something new for the PacBio® team: our SMRT® technology was the subject of a tweet chat hosted by Genome Biology. For one hour, editors at the journal along…
July 30, 2013
Single-Molecule Sequencing Technology Q&A with Nobel Laureate Rich Roberts
BioMed Central has published an interesting Q&A session on its Biome blog with Nobel Laureate Richard Roberts about why he believes in SMRT Sequencing and thinks non-users should take another…
July 29, 2013
As Cores Upgrade to PacBio RS II, Users Report Data and Progress
As PacBio customers are upgrading to the new PacBio® RS II System, some of our core lab users have already begun blogging about the improved results. At the University of…
July 22, 2013
New Genomes for 100K Pathogen Project Sequenced and Finished with PacBio Technology
The 100K Foodborne Pathogen Genome Project announced the contribution of 20 newly finished genomes of microbes responsible for foodborne disease, and we’re pleased to report that they were sequenced and…
July 22, 2013
Whole-Genome Microbial Epigenetics: ASM Workshop videos highlight emerging application of SMRT Sequencing
We recently participated in a workshop on whole-genome microbial epigenetics at the American Society for Microbiology annual meeting in Denver. Using SMRT® Sequencing, the three most common types of bacterial…
July 10, 2013
University of Oslo Scientists Use Long Reads for Unique Look at Cod Genome
Scientists at the University of Oslo’s Centre for Ecological and Evolutionary Synthesis (CEES) have used multi-kilobase sequence reads from the PacBio® RS sequencer to produce a dramatically improved genome assembly…
July 3, 2013
Genome Biology Commentary Discusses the Advantages of SMRT Sequencing
A new commentary in Genome Biology from highly respected scientific authors, including a Nobel Prize winner, highlights the benefits of Single Molecule, Real-Time (SMRT®) Sequencing. The commentary, entitled “The advantages…
July 3, 2013
Using PacBio Sequencing, Scientists Find No Evidence of Horizontal Gene Transfer in Haitian Cholera Strain
A new analysis from public health scientists has found that the cholera strain responsible for the 2010 outbreak in Haiti has a limited ability to add to its genetic repertoire…
June 18, 2013
Back from SFAF, and Eager for More Finished Genomes
Last month’s Sequencing, Finishing, Analysis in the Future (SFAF) meeting in Santa Fe, New Mexico, hosted by Los Alamos National Laboratory, attracted terrific scientists and we really enjoyed hearing about…
June 14, 2013
Two Worlds of Genome Assemblers
by Jonas Korlach, Chief Scientific Officer Finished genomes were the focus of last month’s Sequencing, Finishing, Analysis in the Future (SFAF) meeting in Santa Fe, New Mexico. In addition to…
June 4, 2013
Jonas Korlach Honored by White House as an Immigrant ‘Champion of Change’
Last week the White House held an event to honor eleven Immigrant Innovator “Champions of Change” — the best and brightest from around the world who are helping create American…
May 14, 2013
Nature Methods Paper Demonstrates a Cost-Effective Process for Finishing Genomes
A paper recently published in Nature Methods offers a deep dive into the use of our HGAP and Quiver tools to generate a high-quality genome assembly with an automated, simplified…