Blog
February 4, 2015
High-Quality Genome Assembly and Transcriptome of Cotton Using SMRT Sequencing
A recent research partnership with KeyGene, a Dutch plant genomics and crop improvement company, has resulted in an integrated whole-genome assembly and transcriptome of Gossypium hirsutum, or tetraploid cotton. This…
January 29, 2015
Register Now: Isoform Sequencing Webinars Offer Tips on Method and Analysis
If full-length transcript information would be useful for your research, please join us for two upcoming webinars. Our scientists will offer tips for how to optimize the Iso-Seq™ method with…
January 23, 2015
Breaking New Frontiers in Grass Genomics to Understand Drought Tolerance with the 2014 SMRT Grant Program Winner: Oropetium thomaeum
Emerging from a myriad of interesting genome nominations, from the American cranberry to South American prawns and African Guava, Oropetium thomaeum submitted by Todd Mockler at the Donald Danforth Plant…
January 20, 2015
Looking Ahead: The 2015 PacBio Technology Roadmap
By Jonas Korlach, Chief Scientific Officer All of us at Pacific Biosciences are very proud of the momentum SMRT® Sequencing achieved in 2014, especially due to the more than 500…
January 6, 2015
PAG 2015: SMRT Sequencing and the “Most Interesting Genome” Grant Program
The 23rd annual International Plant and Animal Genome meeting is right around the corner – it’s taking place January 10-14 in sunny San Diego. The meeting has become an important…
December 16, 2014
At ASHI 2014, SMRT Sequencing Meets HLA Typing with Great Results
Earlier this fall, we headed to Denver for ASHI, or the annual meeting of the American Society for Histocompatibility and Immunogenetics. Though we’d attended this conference in the past, this…
December 11, 2014
Review Article: Long-Read Sequencing Offers Better Understanding of Pluripotency
A new review article offers a nice overview of attempts to characterize the transcriptome of human stem cells using RNA-seq, the Iso-Seq™ method, and more. Kin Fai Au and Vittorio…
December 4, 2014
A New Reference Genome for Shigella: SMRT Sequencing of a Historic Sample
In a special issue of The Lancet dedicated to World War I, an article by scientists from the Wellcome Trust Sanger Institute used Single Molecule, Real-Time (SMRT®) Sequencing to decode…
November 12, 2014
New Transcript Study Offers Clues to Pathogenesis of Repeat Disorders Linked to FMR1
It’s been nearly two years since a team of scientists from the University of California, Davis, School of Medicine published the first-ever complete sequence of FMR1, the gene associated with…
November 10, 2014
Nature Paper Offers Novel Sequence, Structural Variant Data for a More Complete Human Genome
A new paper out in Nature extends our view into the human genome and challenges current ideas about genetic variation. “Resolving the complexity of the human genome using single-molecule sequencing”…
October 29, 2014
‘Revolutionizing HLA Typing’: Uppsala’s Ulf Gyllensten on How Long Reads Give Access to New Areas of the Human Genome
In a recent interview with Theral Timpson — part of Mendelspod’s series on long-read sequencing — Ulf Gyllensten, a scientist at Uppsala University, spoke about using PacBio® technology for HLA…
October 21, 2014
Data Release: Whole Human Transcriptome from Brain, Heart, and Liver
In higher eukaryotic organisms, like humans, RNA transcripts from the vast majority of genes are alternatively spliced. Alternative splicing dramatically increases the protein-coding potential of eukaryotic genomes and its regulation…
October 20, 2014
SMRT Sequencing for the HLA Complex: PacBio Goes to ASHI
This week marks the 40th annual meeting of the American Society for Histocompatibility and Immunogenetics, better known in the community as ASHI. The PacBio® team is looking forward to attending;…
October 15, 2014
New Chemistry Boosts Average Read Length to 10 kb – 15 kb for PacBio® RS II
We are pleased to announce the launch of our new reagent kit, P6-C4, which represents the next generation of our polymerase as well as our chemistry. This kit replaces the…
October 10, 2014
ASHG 2014: A New Look at the Human Genome with Long-Read Sequencing
Scientists around the world are getting ready for the annual meeting of the American Society of Human Genetics taking place October 18-22 at the San Diego Convention Center. We’re looking…