Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
PMWC 2018: Sequencing Improvements Power Large-Scale Studies and Clinical Assays
One of our favorite January traditions is taking part in the Precision Medicine World Conference (PMWC), a three-day Silicon Valley event focused on exploring challenges and opportunities in personalized medicine….
Collaborative effort results in high-quality mosquito genome, raising hope for infectious disease control
In an unprecedented crowd-sourced effort stoked by social media, 72 scientists collaborated via 25 conference calls and 3,323 emails to produce a new high-quality Aedes aegypti mosquito genome. Assembled using…
Alternative splicing analysis reveals isoforms associated with FMR1 repeat expansion
In a recent publication, scientists from the University of California, Davis, and PacBio reported results from an investigation of alternative splicing associated with a repeat expansion in the gene linked…
New nematode assembly simplifies search for evolutionary clues
Nematodes are both simple and complex, making them one of the most attractive animal taxa to study basic biological processes, including genome evolution. Studies in the nematode Caenorhabditis elegans, for…
New assembly of wheat progenitor offers clues to genome evolution
Following on the heels of the first nearly complete assembly of the hexaploid bread wheat genome, scientists from the University of California, Davis, the USDA Agricultural Research Service, Johns Hopkins…
Lucky winners: Five more species to receive SMRT sequencing at Sanger Institute
Scientists championed their cases, school children sifted through species, and thousands of members of the public from around the globe took to social media to weigh in. Now the results…
A Fish Tale: Centromeres Prove Central to the Divergence of a Species
The ability to study the speciation of an animal in real-time is a dream come true for evolutionary and developmental biologists. A group of Japanese researchers has gotten that opportunity,…
Creating an Epigenetic Barcode to Accurately Characterize Microbial Communities
Unraveling the role of the microbiome in human health and environmental samples is an emerging priority in scientific study. But despite the best advances in sequencing technology, identifying the bacteria,…
Full-Length HLA Sequencing Improves Accuracy and Resolution for Community Resource
In a new publication, scientists from Anthony Nolan Research Institute and the UCL Cancer Institute present an in-depth analysis of the utility of SMRT Sequencing for Human Leukocyte Antigen (HLA)…
Long-read Koala Assembly Provides Insight into Ongoing Retroviral Invasion
What can one koala tell us about an endemic that threatens the survival of its species? A great deal, it turns out. While doing a deep dive into the genome…
The antibiotic arms race: Tracking K. pneumoniae in a hospital setting
In a recent paper, scientists in Germany call for a genomic database of Klebsiella pneumoniae strains to accelerate strain identification as well as drug-resistance status. To that end, they used…
Investigating splicing of transcripts in cancer cells: SMRT Grant winner announced
We’re pleased to announce the winner of this year’s ‘Open Your Eyes to Isoform Diversity’ SMRT Grant, which was launched during the American Association for Cancer Research annual meeting. The…
Fungal genome study sheds light on pathogenicity in plants
They are colonizers and killers, growing as large as 2,400 acres, leaving devastation in their wake. Armillaria fungi are the cause of root rot disease in forests, fields, parks, and vineyards…
Medicinal plants: Investigating biosynthesis with SMRT sequencing
Three recent publications report results from transcriptome studies of plants often used for medicinal purposes, all powered by SMRT Sequencing and the Iso-Seq method. The papers on ginseng, Huangqi, and…
Sanger celebrates 25 Years by generating 25 high-quality genomes of UK species
We’re pleased to be teaming up with the Wellcome Trust Sanger Institute on a project to celebrate their twenty-fifth anniversary: generating high-quality genome assemblies for 25 species that are integral…