Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
The Sequencing of the Octoploid Strawberry Genome Uncovers its Evolution
By Ángel Vergara Cruces, Universidad de Málaga Plant geneticists have achieved a sweet feat: the first assembly of the octoploid strawberry genome. As reported in Nature Genetics earlier this year,…
AACR 2019 Highlights: Long Reads, Structural Variants, and Iso-Seq Analysis
This month’s meeting of the American Association for Cancer Research (AACR) in Atlanta was a great showcase of the latest academic and translational research in this field. Years ago, the…
Now Available: Sequel II System Delivers ~8 Times as Much Data as Previous System
We’re thrilled to announce the launch of the Sequel II System, reducing project costs and timelines with approximately eight times the data output compared to the previous Sequel System. It…
Rapid Response: A Role for SMRT Sequencing in Infectious Disease Control
Researchers rely on PacBio long-reads for richness and resolution when probing genomes, and these same attributes are becoming increasingly relevant in clinical settings. One field where the technology shows particular…
Smoking out Structural Variants in the Cannabis Genome
With its unique medicinal and psychoactive compounds, the popularity of cannabis is spreading… well, like a weed. Now legal in 10 states for recreational use, and in 33 for medical…
German Shepherd Genome Project Fetches Popular Vote
First there was Shadow, the poodle owned by gene-entrepreneur Craig Venter. Then there was Tasha, a female Boxer. Will the next de-coded dog be Maya, a German Shepherd Dog that…
Now available: Low DNA input workflow for SMRT sequencing
We are pleased to announce the availability of our protocol for template preparation to support low DNA input for sequencing on the Sequel System. The low DNA input workflow features…
Microbial Sequencing Used to Unravel Mysteries of Aquatic Environments
While some microbiologists can study their organisms of interest by growing them in cultures in the lab, many don’t have that luxury. Most microbes and algae cannot be cultured, which…
Complete Genomes Within Reach: Multiplexing Enables Efficient Microbial Sequencing
Research interest in the human microbiome and the roles our bacterial, viral, and single-cell eukaryote co-inhabitants play in health, nutrition, immunity, and disease has exploded. Yet accurately measuring the composition…
Many Studies Show Causal Variant Discovery Potential of SMRT Sequencing
by Jonas Korlach, CSO It’s been really exciting to see a spate of publications coming out that demonstrate the utility of SMRT Sequencing for determining the underlying genetic cause of…
In Study, SMRT Sequencing Provides Higher-Resolution HLA Typing Associated with Improved Patient Survival Rates
In a study just published in the Journal of Biology of Blood and Marrow Transplantation, scientists at the Anthony Nolan Research Institute demonstrated that ultra-high-resolution HLA typing performed with SMRT…
Collaborative Study with Second Genome: Mining Complex Metagenomes for Protein Discovery with Long-Read Sequencing
It seems like there is a new story every week in the mainstream press about the unexpected ways the bacteria living on and within us impact health, disease, and even…
New Isoform-Level Transcriptome Reference Helps Shrimp Industry Ward Off Disease
One of the fastest growing global foods is also one of its most vulnerable. Without an adaptive immune system, the Pacific white shrimp, Litopenaeus vannamei, rely on cellular and humoral…
Two New Reference Genomes Expand Potential for Millet as Super Cereal Crop
The modern world might benefit from a return to our ancient roots by expanding the cultivation of one of the first domesticated crops, broomcorn millet. Foodies will appreciate that the…
New Progress in Representing Population Diversity in Human Genomes
We’re seeing real progress in efforts to better characterize genomic population diversity. That’s particularly good news in light of mounting concerns about the implications of having genomic databases that over-represent…