Blog
May 17, 2022
HiFi sequencing for AAV gene therapy: from discovery and design to production
Recombinant adeno-associated virus (rAAV) is one of the most actively investigated gene therapy vehicles. At its most basic form, an rAAV vector has been stripped of all its components with…
May 12, 2022
The HiFi difference – Getting the right answer
The combined accuracy and length of PacBio HiFi reads is utilized by an ever-increasing number of researchers, with numerous new publications and preprints appearing every week. Several months ago, Illumina…
May 3, 2022
Agrigenomics for pest and disease research
When you’re dealing with insects, fungi and microbes with short life cycles and rapid reproduction, you often encounter highly variable genetics within single populations. The complexities of genetics within…
April 26, 2022
The HiFi difference – haplotype phasing in genome assembly
Most higher organisms are diploid, meaning that each cell carries in its nucleus two copies of the individual’s genome, one from its mother and one from its father. Accurately separating…
April 22, 2022
Earth Day 2022: Investing in genomics to invest in our planet
As we celebrate the 52nd anniversary of Earth Day, PacBio reflects on how the power of genomics can be harnessed in the spirit of this year’s theme: “invest in our…
April 19, 2022
Agrigenomics for genome engineering
Advancements in genome engineering and other programmable molecular techniques are showing great promise in agriculture, with the potential to address food security and industrial sustainability. To be able to…
April 15, 2022
Agrigenomics for crop and livestock breeding
Whether it’s enhancing marker development, facilitating the production of more nutritious food, protecting livestock health, or increasing crop yield, the biological insights gained from comprehensive HiFi sequencing are immeasurable…
April 7, 2022
The HiFi difference – sequencing telomeres
The scientific community is still abuzz from last week’s announcement of the amazing achievement of the first complete sequence of a human genome by the Telomere-to-Telomere (T2T) Consortium. Assembling genomes…
March 31, 2022
A new era of genomics: how a truly complete reference will impact human genetic research
What would be possible if every human genetics researcher had a complete reference genome? Today, researchers use a good – but incomplete – reference genome released in 2013. As…
March 24, 2022
The HiFi difference – full-length RNA sequencing
Through the development of long-read, full-length RNA sequencing methods, the scientific community has recognized a fundamental paradigm shift, “from ‘gene-centric’ to ‘isoform-centric’ understanding of human transcriptomes, owing to the frequent…
March 21, 2022
Genomics in action: PAGBio Day 2022
How sequencing provides actionable insights in agriculture, conservation and ecology. What does genomics in action look like? At PAGBio Day 2022, we heard from scientists using high-quality genomic data…
March 17, 2022
The HiFi difference — true long reads vs synthetic long reads
Long-read PacBio HiFi sequencing has made transformative contributions to many areas of genomics over the past few years, including de novo assembly, calling of all variant types, full-length phased targeted…
March 7, 2022
Obtain more species and MAGs from HiFi shotgun metagenomics data with updated pipelines
Microbial and metagenomics enthusiasts rejoice: newly optimized bioinformatics pipelines are enabling scientists to detect even more species and assemble more single contig metagenomes using HiFi sequencing than ever before…
March 2, 2022
CEO Christian Henry’s vision for the future of PacBio
Today marks an exciting change for PacBio. We’ve updated our logo, and our website looks a bit brighter. But this is more than just a new look. It represents…
February 27, 2022
An interview with Care4Rare – how HiFi sequencing is being used to improve our understanding of rare disease
Over one million Canadians are impacted by rare genetic diseases, and over a third of these remain unsolved. For some families, this has led to decades-long diagnostic odysseys to find…