Blog
September 8, 2022
The HiFi difference – E pluribus unum
Over the past few months, we have highlighted the striking versatility of HiFi sequencing in a series of a dozen blogposts, allowing many different research applications to be performed with…
September 1, 2022
Thwart food-borne contaminants with the extraordinary accuracy of HiFi sequencing
HiFi sequencing delivers the most accurate and comprehensive microbial sequence data possible to give food safety and public health professionals the clarity they need to better understand contaminants and make…
August 26, 2022
The HiFi difference – delivering superior data for proteogenomics
In living cells, it is typically the proteins that are the work horses of carrying out the myriad of biological functions, and that can be subject to aberrant processes that…
August 25, 2022
HiFi sequencing delivers a cutting-edge view of RNA isoforms in cancer
Olga Anczukow (@OlgaAnczukow), PhD, a leading expert on breast cancer at the Jackson Laboratory, recently presented on how HiFi sequencing (PacBio’s highly accurate long-read sequencing technology) with the Iso-Seq method…
August 10, 2022
The HiFi difference: powering biodiversity genomics
In a new preprint, entitled Realizing the promise of biodiversity genomics with highly accurate long reads, a group of researchers from Utah State, BYU, the LOEWE Centre for Translational Biodiversity…
August 3, 2022
The HiFi difference: resolving the most complex genomic regions
The combined accuracy, read length, and coverage uniformity of PacBio HiFi sequence reads enables the characterization of many previously inaccessible regions in the genome. Two new preprints by Oscar Rodriguez,…
July 22, 2022
The HiFi difference: enabling the human pangenome reference
A few weeks ago, we described the use of HiFi sequencing to drive the paradigm shift from a single reference genome to a pangenome derived from a diverse set of…
July 20, 2022
HiFi sequencing tools to help transform AAV-based gene therapy
Leading researchers in AAV-based gene therapy development recently presented how they are leveraging PacBio long-read sequencing technology to advance product design and performance. Background Building treatments for individuals…
July 15, 2022
5 weeks, 20 cities, countless connections: Discoveries Roadshow 2022
This spring, leading life science experts from 26 countries gathered at PacBio organized events to discuss exciting developments in HiFi sequencing technology, explore new genomic applications, and foster human…
July 1, 2022
The HiFi difference: enabling the era of reference pan-genomes
PacBio HiFi sequencing has been utilized to generate reference-quality genomes in many studies, most notably in finally completing a human genome. Following this work, the Human Pangenome Reference Consortium…
June 23, 2022
The HiFi difference – More precise genomes for precision medicine
More precise data provided by PacBio HiFi sequencing can have a marked impact on the resolving power in genetic association studies and decrease the required cohort sizes. As a recent…
June 7, 2022
Shotgun metagenomics with HiFi reads: now more affordable
Unlocking the secrets of complex communities and microbiomes represents one of the most exciting frontiers in microbiology, with the potential to revolutionize our understanding of human health, food…
June 1, 2022
The HiFi difference — Not all gigabases are created equal
PacBio HiFi sequencing for the de novo genome assembly of microbial, fungal, plant, animal and human genomes has been described in hundreds of publications, and its best-in-class performance has been…
May 23, 2022
Get more for less — Single-gene testing with HiFi sequencing
Is it possible to save time and resources while also increasing the quality of data you receive? For many, this might seem impossible. But recently, some researchers have found that…
May 19, 2022
HiFi metagenomics: more samples, more species, more MAGs
We recently brought together Jeremy Wilkinson, Ph.D. (@jewilki), Microbiome and Metagenomics Market Lead at PacBio, Xiaowen Feng, Ph.D. (@0xfxfxf), Postdoctoral Fellow at Dana-Farber Cancer Institute and Harvard Medical School, and…