Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Scientists Publish New Methylation Analysis Protocols Using SMRT Sequencing
Scientists from the Icahn School of Medicine at Mount Sinai and the University of Saskatchewan teamed up to develop an innovative approach to methylation analysis using Single Molecule, Real-Time (SMRT®)…
Updated! Data Release: Human MCF-7 Transcriptome
UPDATE: Our R&D team has added a new dataset for the MCF-7 human breast cancer transcriptome, originally released in 2013. The new results were produced using 28 SMRT® Cells with…
Attend Our Worldwide User Meetings & SMRT Informatics Developers Conference
If you’d like to hear about the latest applications of SMRT® Sequencing from users, we have several events coming up. Our worldwide user group meetings and workshops feature PacBio users…
In Assembler Evaluation, Scientists Recommend Non-hybrid Approach to Bacterial Genomes
A new publication in Nature Scientific Reports recommends using only the PacBio® system to sequence bacterial genomes for the best chance of generating an accurate and finished assembly. The paper,…
Microbial Madness: Talks, Posters, and SMRTest Microbe Grant Program at ASM 2015
For some people, Mardi Gras and beignets are big attractions in New Orleans — but for us it’s all about the annual conference of the American Society for Microbiology. With…
New MHAP Algorithm Delivers Fast, High-Quality Genome Assemblies
A new publication in Nature Biotechnology reports the development of a lightning-fast genome assembly pipeline optimized for long reads. Scientists from the University of Maryland and the National Biodefense Analysis…
Tutorial on the Iso-Seq Method: Applications, Protocol, and Experimental Design
If you missed our recent webinar on isoform sequencing with the PacBio® platform, we’ve made the full recording available for on-demand access. “Iso-Seq™ Method: Sample Prep and Experimental Design for…
PAG Grant Winner: Rainforest Tree Homalanthus nutans to get the SMRT Treatment
We’re pleased to announce the winner of our recent “Most Interesting Genome in the World” grant competition. Congratulations to Jay Keasling and Jeff Wong at the University of California, Berkeley!…
In Study, Continuous Long Reads Outperform Synthetic Long Reads for Resolving Tandem Repeats
Scientists from Argentina and Brazil published the results of a study comparing long-read approaches to characterize the genome structure of a highly complex region of the Y chromosome in Drosophila…
New Solutions for Comprehensive and Efficient Targeted Sequencing and Multiplexing of Samples
We are proud to announce the introduction of several new solutions for targeted sequencing and sample multiplexing on the PacBio® Sequencing System. New Targeted Sequencing Workflow through Collaboration with Roche…
On DNA Day, Celebrating New Firsts
Hooray for DNA! We’re excited to celebrate this day as it it honors two major accomplishments in the field: the 1953 publication of the structure of DNA, and the 2003…
AACR 2015: A Novel Look at Cancer, and a New SMRT Sequencing Grant Program
We’re looking forward to the annual meeting of the American Association for Cancer Research, which kicks off this weekend in Philadelphia. From directly phasing variants to sequencing full-length gene isoforms…
In Genome-wide Study, Long Reads Prove Critical for Structural Variant Discovery
In a paper just published in BMC Genomics, a team of scientists led by Baylor’s Human Genome Sequencing Center reports a thorough analysis of structural variation in a personal genome….
In Chronic Myeloid Leukemia Study, SMRT Sequencing Detects Resistance Mutations Early, New Splice Isoforms and More
Scientists from Uppsala University report in a recent paper that using the Iso-Seq™ method with SMRT® Sequencing allowed them to detect and monitor mutations in the BCR-ABL1 fusion gene for…
AGBT Highlights, Day Three: Genomic Medicine, Population Specific Genomes, Goats & Influenza
Day 3 of the AGBT conference was packed with interesting talks – we’ve covered a few highlights below. Admittedly, it took a little more caffeine than usual to power through…