Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Thwart food-borne contaminants with the extraordinary accuracy of HiFi sequencing
HiFi sequencing delivers the most accurate and comprehensive microbial sequence data possible to give food safety and public health professionals the clarity they need to better understand contaminants and make…
The HiFi difference – delivering superior data for proteogenomics
In living cells, it is typically the proteins that are the work horses of carrying out the myriad of biological functions, and that can be subject to aberrant processes that…
HiFi sequencing delivers a cutting-edge view of RNA isoforms in cancer
Olga Anczukow (@OlgaAnczukow), PhD, a leading expert on breast cancer at the Jackson Laboratory, recently presented on how HiFi sequencing (PacBio’s highly accurate long-read sequencing technology) with the Iso-Seq method…
The HiFi difference: powering biodiversity genomics
In a new preprint, entitled Realizing the promise of biodiversity genomics with highly accurate long reads, a group of researchers from Utah State, BYU, the LOEWE Centre for Translational Biodiversity…
The HiFi difference: resolving the most complex genomic regions
The combined accuracy, read length, and coverage uniformity of PacBio HiFi sequence reads enables the characterization of many previously inaccessible regions in the genome. Two new preprints by Oscar Rodriguez,…
The HiFi difference: enabling the human pangenome reference
A few weeks ago, we described the use of HiFi sequencing to drive the paradigm shift from a single reference genome to a pangenome derived from a diverse set of…
HiFi sequencing tools to help transform AAV-based gene therapy
Leading researchers in AAV-based gene therapy development recently presented how they are leveraging PacBio long-read sequencing technology to advance product design and performance. Background Building treatments for individuals…
5 weeks, 20 cities, countless connections: Discoveries Roadshow 2022
This spring, leading life science experts from 26 countries gathered at PacBio organized events to discuss exciting developments in HiFi sequencing technology, explore new genomic applications, and foster human…
The HiFi difference: enabling the era of reference pan-genomes
PacBio HiFi sequencing has been utilized to generate reference-quality genomes in many studies, most notably in finally completing a human genome. Following this work, the Human Pangenome Reference Consortium…
The HiFi difference – More precise genomes for precision medicine
More precise data provided by PacBio HiFi sequencing can have a marked impact on the resolving power in genetic association studies and decrease the required cohort sizes. As a recent…
Shotgun metagenomics with HiFi reads: now more affordable
Unlocking the secrets of complex communities and microbiomes represents one of the most exciting frontiers in microbiology, with the potential to revolutionize our understanding of human health, food…
The HiFi difference — Not all gigabases are created equal
PacBio HiFi sequencing for the de novo genome assembly of microbial, fungal, plant, animal and human genomes has been described in hundreds of publications, and its best-in-class performance has been…
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Single-gene testing with HiFi sequencing
Is it possible to save time and resources while also increasing the quality of data you receive? For many, this might seem impossible. But recently, some researchers have found that…
HiFi metagenomics: more samples, more species, more MAGs
We recently brought together Jeremy Wilkinson, Ph.D. (@jewilki), Microbiome and Metagenomics Market Lead at PacBio, Xiaowen Feng, Ph.D. (@0xfxfxf), Postdoctoral Fellow at Dana-Farber Cancer Institute and Harvard Medical School, and…
HiFi sequencing for AAV gene therapy: from discovery and design to production
Recombinant adeno-associated virus (rAAV) is one of the most actively investigated gene therapy vehicles. At its most basic form, an rAAV vector has been stripped of all its components with…