Build your workflow with PacBio Compatible

PacBio is partnering with 10x Genomics through the 10x Compatible Partner Program and PacBio Compatible to unlock a multidimensional approach to sequencing at exceptional resolution and accuracy. This partnership demonstrates compatibility of the MAS-Seq for 10x Single Cell 3′ kit and Kinnex single-cell RNA kit for 10x Chromium singlecell libraries to be paired with PacBio’s long read sequencing platforms.

Agilent is a compatible partner for end-to-end targeted sequencing workflows including automation, library prep, and data analysis. This partnership leverages the ClearSeq Comprehensive Cancer panel and the accuracy of SBB technology to confidently identify disease-associated variants and optimize the molecular profiling of cancers. Targeted sequencing is enabled by Agilent’s SureSelect Custom DNA Target Enrichment Probes and PacBio’s sequencing by binding (SBB) technology. Additionally, Agilent’s Femto Pulse instrument is recommended for accurate generation of large-insert libraries for de novo large genome sequencing projects and other PacBio applications leveraging multi-kilobase read lengths.

Google Health is a strategic development partner for DeepConsensus integration into the PacBio Revio system. Google Health’s DeepVariant software analysis of PacBio HiFi data won best performance in variant calling for all benchmark regions in the Precision FDA Truth Challenge v2.

IDT has evolved as a leading DNA synthesis company to provide genomics solutions across NGS, CRISPR, Synthetic Biology, and PCR, equipping researchers with the right tools when they need them. Combining xGen™ high-conversion NGS library prep technology and the short-read PacBio Onso platform has demonstrated an ability to detect low allelic frequency variants in low input samples.

Qiagen is a partner for PacBio SBB workflows, providing end-to-end targeted sequencing including automation, library prep, and data analysis. Qiagen and PacBio are partnering on cfDNA workflows for the Onso sequencing platform.

Sentieon is a data analysis partner for processing and accelerating PacBio FASTQ to VCF data processing. Sentieon’s DNAscope tool takes advantage of the improved quality and long read length of PacBio HiFi reads to perform quick and accurate variant calling using specially calibrated machine learning models.

PacBio has partnered with Twist Bioscience to deliver long-read target enrichment panels. The initial portfolio of products focuses on challenging, medically relevant genes (Dark Genes panel) and pharmacogenomics (Long Read PGx panel). Custom panel capability broadens access to the benefits of long-read HiFi sequencing like accurate variant detection including structural variants and phasing. This partnership also combines the outstanding accuracy of SBB technology with the Twist Exome 2.0 panel: 50x coverage of >80% target bases. By partnering with Twist, PacBio can deliver a targeted sequencing solution that is high throughput and cost-effective while also being supported end-to-end.

Watchmaker Genomics applies advanced enzymology to enable breakthrough applications for the reading, writing, and editing of DNA and RNA. The product portfolio includes enzymes and kits for NGS library preparation, featuring solutions that are rapid, sensitive, and highly automatable. The Watchmaker DNA library prep portfolio is compatible with Onso sequencing to deliver superior sequence coverage and accuracy with a wide range of samples, including cfDNA and FFPE samples.