Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
AGBT 2015: PacBio Workshop Review & Recording
Our AGBT workshop attracted more than 500 attendees thanks to the high-profile speakers who shared their perspectives on human genomic research. Because of the exclusivity of AGBT, we decided to…
AGBT Highlights, Day Two: Human Genomes, Variation, and the Rapidly Evolving Y Chromosome
The first full day of AGBT kicked off with a great talk from Evan Eichler from the University of Washington. Starting with the premise that characterizing genetic variation is key…
AGBT Highlights, Day One: Advancing Human Reference Assembly & Sequencing in the Clinic
It is great to be here in Marco Island for the AGBT meeting! The 16th annual meeting hit the ground running with a pre-meeting workshop hosted by the Genome Reference…
AGBT 2015: Seeing the Genome in a New Light (Sunshine?)
Like many others, we’re looking forward to an exciting week of science and sun at the 16th annual Advances in Genome Biology and Technology (AGBT) conference! We’re hosting a lunch…
High-Quality Genome Assembly and Transcriptome of Cotton Using SMRT Sequencing
A recent research partnership with KeyGene, a Dutch plant genomics and crop improvement company, has resulted in an integrated whole-genome assembly and transcriptome of Gossypium hirsutum, or tetraploid cotton. This…
Register Now: Isoform Sequencing Webinars Offer Tips on Method and Analysis
If full-length transcript information would be useful for your research, please join us for two upcoming webinars. Our scientists will offer tips for how to optimize the Iso-Seq™ method with…
Breaking New Frontiers in Grass Genomics to Understand Drought Tolerance with the 2014 SMRT Grant Program Winner: Oropetium thomaeum
Emerging from a myriad of interesting genome nominations, from the American cranberry to South American prawns and African Guava, Oropetium thomaeum submitted by Todd Mockler at the Donald Danforth Plant…
Looking Ahead: The 2015 PacBio Technology Roadmap
By Jonas Korlach, Chief Scientific Officer All of us at Pacific Biosciences are very proud of the momentum SMRT® Sequencing achieved in 2014, especially due to the more than 500…
PAG 2015: SMRT Sequencing and the “Most Interesting Genome” Grant Program
The 23rd annual International Plant and Animal Genome meeting is right around the corner – it’s taking place January 10-14 in sunny San Diego. The meeting has become an important…
At ASHI 2014, SMRT Sequencing Meets HLA Typing with Great Results
Earlier this fall, we headed to Denver for ASHI, or the annual meeting of the American Society for Histocompatibility and Immunogenetics. Though we’d attended this conference in the past, this…
Review Article: Long-Read Sequencing Offers Better Understanding of Pluripotency
A new review article offers a nice overview of attempts to characterize the transcriptome of human stem cells using RNA-seq, the Iso-Seq™ method, and more. Kin Fai Au and Vittorio…
A New Reference Genome for Shigella: SMRT Sequencing of a Historic Sample
In a special issue of The Lancet dedicated to World War I, an article by scientists from the Wellcome Trust Sanger Institute used Single Molecule, Real-Time (SMRT®) Sequencing to decode…
New Transcript Study Offers Clues to Pathogenesis of Repeat Disorders Linked to FMR1
It’s been nearly two years since a team of scientists from the University of California, Davis, School of Medicine published the first-ever complete sequence of FMR1, the gene associated with…
Nature Paper Offers Novel Sequence, Structural Variant Data for a More Complete Human Genome
A new paper out in Nature extends our view into the human genome and challenges current ideas about genetic variation. “Resolving the complexity of the human genome using single-molecule sequencing”…
‘Revolutionizing HLA Typing’: Uppsala’s Ulf Gyllensten on How Long Reads Give Access to New Areas of the Human Genome
In a recent interview with Theral Timpson — part of Mendelspod’s series on long-read sequencing — Ulf Gyllensten, a scientist at Uppsala University, spoke about using PacBio® technology for HLA…