Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Introducing the Sequel System: The Scalable Platform for SMRT Sequencing
We are excited to announce our newest Single Molecule, Real-Time sequencer, the Sequel™ System. Watch this short video to learn about this exciting evolution in SMRT® Sequencing. The Sequel System…
Marc Salit at NIST: Defining Standards for the Human Genome
In the first podcast of a new series on the applications of long-read sequencing, Mendelspod host Theral Timpson interviewed Marc Salit, leader of the Genome Scale Measurements Group at the…
At Genome in a Bottle Workshop, Progress on New Reference Materials
Genome in a Bottle consortium The National Institute of Standards and Technology held its latest Genome in a Bottle workshop last month in Gaithersburg, Md., and we were honored to…
SMRTest Microbe Grant Winner: Identifying Antibiotic Resistance Mechanisms with SMRT Sequencing
We’re pleased to announce the winner of our recent “SMRTest Microbe” grant competition. Congratulations to Dr. Erin Price at the Menzies School of Health Research in Australia! The grant program,…
SMRT Data Analysis: Updates from our Developers Conference
Last month we hosted a SMRT® Informatics Developers Conference, bringing together 150 developers with a passion for improving tools and resources. Our team came back brimming with enthusiasm for tools…
Webinar: Long Fragment Capture for SMRT Sequencing
Roche recently posted this recording of a webinar walking through long fragment capture with SMRT® Sequencing. “Long Genomic DNA Fragment Capture and SMRT Sequencing Enables Accurate Phasing of Cancer and…
In Bacterial Study, Scientists Link Epigenetic Switch to Virulence, Antibiotic Resistance, and More
Scientists from Griffith University, Ohio State University College of Medicine, and other institutions recently published a detailed study of phase-variable expression of a DNA methyltransferase in non-typeable Haemophilus influenzae, the…
The Gapless Assembly: Scientists Describe Workflow for Producing Complete Eukaryote Genome
Sunflowers with verticillium wilt caused by V. dahliae In a new mBio publication, scientists from Wageningen University and KeyGene in The Netherlands report results from several strategies used to assemble…
Using SMRT Sequencing, Scientists Uncover Unexpected Transcript Diversity in Fungi
A new PLoS One publication from scientists at the Joint Genome Institute, University of Minnesota, and other organizations demonstrates that fungal genomes may contain far more transcript diversity than previously…
SMRT Sequencing Provides Novel View of Long-Term Viral Evolution in a Single Patient
A group of scientists from the University of Pittsburgh School of Medicine and New York University used long-read sequencing from PacBio for a remarkable new study characterizing influenza virus evolution…
Webinar: Anthony Nolan’s Neema Mayor Reports on HLA Typing with Long Reads
Following the recent paper about HLA typing from scientists at Anthony Nolan Research Institute, we thought readers might enjoy this webinar from Neema Mayor, a scientist at the institute and…
SMRT Sequencing Contributes to Detection of DNA Methylation in C. elegans
A recent paper in the journal Cell presents novel findings of DNA methylation in C. elegans, an organism previously believed not to have such epigenetic marks. Scientists used several approaches…
The Festival of Genomics Review: A Celebration of Long Reads
At the inaugural Festival of Genomics event in Boston, more than 1,500 people turned out to see what was billed as a conference unlike any other. The meeting was indeed…
Nature Methods Paper Uses Long-Read Data for Highly Contiguous Diploid Human Genome
A new publication in Nature Methods describes a new single-molecule assembly approach that resulted in “the most contiguous clone-free human genome assembly to date,” according to lead authors Matthew Pendleton,…
SMRT Data Delivers for Next-Generation HLA Typing at Anthony Nolan Research Institute
A new publication in PLoS One from authors at Anthony Nolan’s Research Institute describes a feasibility study for HLA typing using SMRT® Sequencing. The research institute, where the world’s first…