Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
SMRT Sequencing and a Bit of Luck Help Swiss Microbiologists Solve Decades-Old Mystery
It’s a murder mystery of massive proportion, albeit on a miniature scale: Male-killing among several species of insects, caused by selfish symbiotic bacteria. Swiss researchers believe they have finally solved…
Sequel System 6.0 Release Offers a New Paradigm in DNA Sequencing: Highly Accurate Single-Molecule Long Reads
Today we’re pleased to announce the release of Sequel System 6.0, including new software, consumable reagents and a new SMRT Cell. Combined, the enhancements in the release improve the performance and affordability of…
Data Release: Highest-Quality, Most Contiguous Individual Human Genome Assembly to Date
We’re proud to announce the release of the most contiguous diploid human genome assembly of a single individual to date, representing the nearly complete DNA sequence from all 46 chromosomes…
Sanger Institute Birthday Gift to Scientists: 25 New Wildlife Genomes to Support Conservation and Science
King scallops are more genetically diverse than we are? The Roesel’s bush cricket’s genome is four times the size of ours? These are just some of the findings made by…
Beloved Barn Swallow Gets SMRT Sequencing “Platinum Genome” Treatment
UPDATED Dec. 3, 2018 Congratulations to the Italian team on the publication of their European barn swallow genome! The paper is now available at GigaScience. ORIGINAL POST Oct. 3, 2018 With…
Iso-Seq SMRT Grant Winner to Study Alternative Splicing in Neurons
Xiaochang Zhang, an assistant professor at the University of Chicago, is poised to get a powerful new data set to help his team understand the role of alternative splicing in…
Must-Have PacBio Applications & Services: Getting the Most from SMRT Sequencing
In addition to the most common applications, like whole genome sequencing for de novo assembly, there are several other features you can utilize to advance your science or incorporate to…
Building a Digital Genome Ark: Vertebrate Genome Project Releases 15 New Reference Genomes
When creating a global genomic ark of creatures great and small, scientists are turning to the comprehensive coverage and quality of PacBio sequencing. The Vertebrate Genomes Project (VGP), an international…
How to Incorporate New Features into Your Sequencing Services Menu
Many people who run a sequencing core lab would prefer to focus on science instead of business, but all core lab managers know that it’s imperative to keep a steady…
New Look at Breast Cancer Cell Line Sheds Light on Structural Complexity
In an exciting paper that made the cover of Genome Research, scientists from Cold Spring Harbor Laboratory and collaborating institutions report the genome sequence and transcriptome of a commonly used…
Webinar Summary: Developing Benchmark Sets for Structural Variants
A map of every individual’s genome will soon be possible, but how will we know if it is correct? Benchmarks are needed in order to check the performance of sequencing,…
International Eagle Conservation Efforts Bolstered By New Genome Release
Genetics is not only key to discovering and tracing new traits in an organism, but also conserving old ones — and in some cases, the species itself. A deep understanding…
PacBio Sequencing Reveals Food Processing & Pathogenic Strains of Yeast are the Same Species
What’s in a name? Too much, when it comes to the taxology of yeast, it turns out. Scientists from University College of Dublin have found that two distinctly named species…
Something to Crow About: SMRT Sequencing Aids Conservation of Rare Hawaiian Bird
Brought to the brink of extinction, the future of Hawaii’s only lineage of the crow family (Corvidae) is looking up thanks to intensive conservation genomics efforts using PacBio de novo…
Diversity of Unexpected CRISPR Edits Revealed by SMRT Sequencing
A new Nature Biotechnology publication is sending reverberations through the CRISPR and gene therapy communities. The discovery that the widely used CRISPR/Cas9 method results in far more genomic changes than…