Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Looking Forward to Sequencing Advances and Novel Findings at PMWC 2019
Advances in personalized medicine — whether it’s the discovery of a new pathogenic variant or a success story about a patient treated with a tailored therapy — seem to be…
The Genomic Gift Worth Giving: New Assembly Could Help Conserve Declining Turtle Dove Populations
You may be more likely to get five gold rings or three French hens than two Turtle doves this Christmas. The subject of the famous holiday carol is in precipitous…
New Low-Input Protocol Enables High-Quality Genome Created from Single Mosquito
UPDATED January 18, 2019 This paper is now available at Genes. ORIGINAL POST December 19, 2018 High-quality reference and de novo genomes have been celebrated by geneticists, population biologists and conservationists…
Alzheimer’s Study Reveals First Somatic Gene Recombination Found in Human Neurons
Scientists in California recently released exciting results that could offer an entirely new approach to treating the most common form of Alzheimer’s disease. The project, which was reported in a…
A Sweet Sequence: Sugarcane Genome Assembly After Five-Year Collaborative Effort
It took nearly 20 years until the technology was right, and five years of hard graft by more than 100 scientists from 16 institutions, but the result was worth it,…
Targeted PacBio Sequencing Adds to Scientific Arsenal in Evolutionary Arms Race
Cotton crops the world over have benefited from the pest-killing protein from Bacillus thuringiensis (Bt), first used in sprays and then, in 1996, transgenic crops, resulting in reduced insecticide use,…
Barn Swallow Project Helps Introduce PacBio Long Read Technology to Italy
Its reliable return to the same spot year after year has made the barn swallow a beloved symbol of Spring and safe passage, for mariners and landlubbers alike. But our…
Tracking the Tuna: How PacBio Sequencing Could Help Save the “King of the Sea”
Their bodies are big, bony and… warm? Unique among bony fish, Atlantic, Pacific and Southern bluefin tuna have a rare endothermic physiology that has garnered great interest among scientists. Like…
At ASHG 2018, Workshop Speakers Discuss SMRT Sequencing Applications for Human Disease
Last month’s annual meeting of the American Society of Human Genetics in San Diego was a terrific reminder of how much progress is being made in this field — both…
An Interview with Leslie Vosshall: Buzzing About the New Mosquito Reference Genome
The new reference genome for Aedes aegypti, just published in Nature, famously got its start through a crowdsourced effort on social media, beginning with a tweet from Rockefeller University scientist…
North American User Group Meeting: Highlights in Human, Animal, Insect, and Microbes
Many thanks to all the PacBio users who attended our annual user group meeting, hosted in St. Louis for the first time. It was great to see so many people…
Fishing for Human-Specific Isoforms
When scientists want to investigate human-specific evolution, the best place to start is often with a comparison to our closest cousins, the great apes. Some recent high-quality PacBio genome assemblies…
SMRT Grant Winner: Preventing Infection for Premmies
We’re pleased to announce the winner of the 2018 Microbial Genomics SMRT Grant. Mark Webber, Research Leader at Quadram Institute Bioscience in the UK, will get free SMRT Sequencing and…
Genetic Code of All Plants, Animals, Protozoa, and Fungi to be Sequenced with Help of PacBio
It’s one of the most ambitious sequencing projects ever attempted — the assembly of all 1.5 million known species of animals, plants, protozoa and fungi on Earth — and SMRT…
Smell of Success: Garlic Study Validates New Approach to Transcriptome Association
Genome-wide association studies (GWAS) may be powerful tools for the identification of genes underlying complex traits, but what if you have an incredibly complex, uncharacterized genome, with no sequenced progenitor…