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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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The HiFi difference — true long reads vs synthetic long reads

Long-read PacBio HiFi sequencing has made transformative contributions to many areas of genomics over the past few years, including de novo assembly, calling of all variant types, full-length phased targeted…

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Obtain more species and MAGs from HiFi shotgun metagenomics data with updated pipelines

Microbial and metagenomics enthusiasts rejoice: newly optimized bioinformatics pipelines are enabling scientists to detect even more species and assemble more single contig metagenomes using HiFi sequencing than ever before…

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CEO Christian Henry’s vision for the future of PacBio

Today marks an exciting change for PacBio. We’ve updated our logo, and our website looks a bit brighter. But this is more than just a new look. It represents…

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An interview with Care4Rare – how HiFi sequencing is being used to improve our understanding of rare disease

Over one million Canadians are impacted by rare genetic diseases, and over a third of these remain unsolved. For some families, this has led to decades-long diagnostic odysseys to find…

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How far we’ve come part three: Animal genomics

As we close out PAGBio Day 2022, there is one more key part of genomic natural history to consider – animal genomics. As we’ve outlined in prior posts,…

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When genomics gets tough, the tough get HiFi: Users share stories of PacBio enabled science at global summit

Got an impossible polyploid or highly repetitive plant gene, or perhaps an enormous fungal genome or complex microbial community? Have an impossible dream of cracking pandemic, epidemic & endemic biology,…

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How far we’ve come part two: Plant genomics

Plant genomes are notoriously difficult to assemble. They are large and complex, with varying levels of ploidy. In fact, the genome of one of the most well-known model species,…

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How far we’ve come part one: Insect genomics

Much has changed since the first insect genome assembly (Drosophila melanogaster) was published in 2000. With PAGBio Day 2022 registration kicking off this week, we thought it was…

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Omicron and beyond: HiFiViral Kit provides labs with a future-proof solution for emerging COVID-19 variants

As news of yet another SARS-CoV-2 variant dominates headlines, the need for a truly comprehensive solution to identify and understand the rapidly mutating virus becomes even more important. From…

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Q&A: Catching up with our most recent SMRT Grant winners before the New Year

More than 7,500 varieties of apples grow across almost every region on the planet. With growing threats to global food security, they’re affordable, packed full of vitamins, and an excellent…

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Announcing our plant and animal SMRT Grant winners: Sequencing a pangenome to feed a growing population

Working to revolutionize apple agrigenomics at one of the world’s top orchards Leading scientists are constantly searching for innovative ways to amplify and apply their research. So, it came as…

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Introducing first fully-kitted solution for SARS-CoV-2 surveillance and microbial whole genome assembly with HiFi sequencing

These developments advance the ability of laboratories to identify and track infectious disease threats SARS-CoV-2 mutates rapidly but a new solution is now available for public health laboratories in the…

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ASHG 2021: Improving Human Health through Genomics with HiFi Sequencing

The PacBio team recently attended the American Society of Human Genetics (ASHG) 2021 Virtual Meeting. The meeting provided a forum for the presentation and discussion of cutting-edge science in all…

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Our Latest SMRT Grant Winner: HiFi Sequencing to Understand Microbial World

At PacBio, we understand the profound importance of microbial research. As the foundation of the biosphere and major determinants of human health, microbes claim a primary, fundamental role in…

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The Series that Made Our Summer – From Microbes to Metagenomes

The dog days of summer might be behind us, but our four-part Microbial Genomics Webinar Series is sticking around as a focal point of the summer. From the end…

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