Blog
May 24, 2023
Beyond short reads: Harnessing long-read sequencing for population-scale genomic insights
Large-scale population sequencing programs have a number of important research goals and outcomes. These include: Generating a comprehensive catalogue of genetic variation to reflect the genetic diversity in a target…
May 18, 2023
Sequencing 101: Sequencing coverage
This article explores sequencing coverage fundamentals. Uncover key concepts and discover how highly accurate long-read sequencing provides a comprehensive view of the genome, at any coverage level. What is sequencing…
April 27, 2023
HiFi whole genomes could one day replace short-read genome and exome sequencing
In recent years, whole exome sequencing (WES) has become a popular method for identifying the genetic underpinnings of disease in both research and clinical settings. However, because an exome is…
April 25, 2023
The HiFi difference – a better cell atlas with full-length isoform sequencing
Understanding the myriad of different cell types, states, and their functions is essential to understanding biology. Cell atlas projects and consortia aim to map different cell types in tissues, organs,…
April 21, 2023
Earth Day 2023: Can microbial communities turn plastic waste into sustainable food?
With Earth Day almost here, it is important to remember that our planet is made up of countless interconnected parts, from vast oceans to the microscopic world of microbes. Despite…
April 20, 2023
VAMOS! Discover hidden VNTRs with long reads
See how the Chaisson lab created a new method to characterize human VNTR variation with PacBio long-read sequencing. Structural variants are hard to find with short-read sequencing methods At present,…
April 14, 2023
HiFi metagenomics sees performance enhancements across the board
The Revio system offers faster and more cost-effective long-read sequencing for metagenomics researchers, allowing for more high-quality and complete microbial datasets and access to new frontiers of discovery. The best…
April 11, 2023
The power of accurate long-read RNA sequencing for fusion gene detection in cancer research
pbfusion is a new software tool for detecting gene fusions and other transcriptional abnormalities in PacBio Iso-Seq data. The advancement of cancer research depends on the ability to accurately detect…
March 28, 2023
Long-read sequencing: the key to a more complete cancer transcriptome
Uncover the mysteries of RNA dysregulation in cancer Our understanding of the complex biology of cancers is currently limited by the sequencing technology that we have available. For example, a…
March 21, 2023
Scaling long-read sequencing throughput and accessibility with deep learning and NVIDIA
Written by: Menzies Chen, Director, Product Management, Informatics With the launch of the Revio system, PacBio is bringing a host of technologies together to increase scale for HiFi long-read…
March 9, 2023
Introducing HiFiCNV – copy number calling optimized for HiFi reads
Get more from your HiFi reads with HiFiCNV, a powerful new software tool for capturing large copy number variants throughout the genome. Why CNVs and HiFi reads are important Copy…
March 7, 2023
Shining a light on dark genes
Countries around the world have recognized the value of precision health and population genomics research initiatives. They have launched efforts to sequence thousands to millions of genomes in order to…
March 2, 2023
Sequencing 101: long-read sequencing
Last updated: 30 MAR 2026 Long-read sequencing technologies such as PacBio HiFi sequencing are quickly becoming the new gold standard in genomics research. This article provides an introductory look at…
February 27, 2023
A sound approach to rare disease research: a day in the life of Dr. Eliot Shearer
Individual rare diseases affect a small portion of the population. However, because there are over 7,000 known rare diseases, they are, in fact, somewhat common. It is estimated that around…
February 23, 2023
Understanding rare diseases: why research matters
If you know someone affected by a rare disease, next week marks an important day for awareness and education in the rare disease community. Anyone can be affected by rare…