Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
HiFi metagenomics sees performance enhancements across the board
The Revio system offers faster and more cost-effective long-read sequencing for metagenomics researchers, allowing for more high-quality and complete microbial datasets and access to new frontiers of discovery. The best…
The power of accurate long-read RNA sequencing for fusion gene detection in cancer research
pbfusion is a new software tool for detecting gene fusions and other transcriptional abnormalities in PacBio Iso-Seq data. The advancement of cancer research depends on the ability to accurately detect…
Long-read sequencing: the key to a more complete cancer transcriptome
Uncover the mysteries of RNA dysregulation in cancer Our understanding of the complex biology of cancers is currently limited by the sequencing technology that we have available. For example, a…
Scaling long-read sequencing throughput and accessibility with deep learning and NVIDIA
Written by: Menzies Chen, Director, Product Management, Informatics With the launch of the Revio system, PacBio is bringing a host of technologies together to increase scale for HiFi long-read…
Introducing HiFiCNV – copy number calling optimized for HiFi reads
Get more from your HiFi reads with HiFiCNV, a powerful new software tool for capturing large copy number variants throughout the genome. Why CNVs and HiFi reads are important Copy…
Shining a light on dark genes
Countries around the world have recognized the value of precision health and population genomics research initiatives. They have launched efforts to sequence thousands to millions of genomes in order to…
Sequencing 101: long-read sequencing
Last updated: 30 MAR 2026 Long-read sequencing technologies such as PacBio HiFi sequencing are quickly becoming the new gold standard in genomics research. This article provides an introductory look at…
A sound approach to rare disease research: a day in the life of Dr. Eliot Shearer
Individual rare diseases affect a small portion of the population. However, because there are over 7,000 known rare diseases, they are, in fact, somewhat common. It is estimated that around…
Understanding rare diseases: why research matters
If you know someone affected by a rare disease, next week marks an important day for awareness and education in the rare disease community. Anyone can be affected by rare…
HiFi long-read sequencing brings more accuracy to population genomics studies
Population genomics initiatives are gaining traction around the world. There are currently more than 20 active programs spread around the globe, and these programs aim to sequence millions of…
Introducing Paraphase by PacBio —
an informatics method for uncovering secrets of spinal muscular atrophy
For the first time, PacBio is enabling high-throughput, comprehensive profiling of SMN1 and SMN2 with an all-new software tool called Paraphase. Since the first known case of spinal muscular…
The HiFi difference – large-scale, high-quality data for all of us
A new preprint entitled Utility of long-read sequencing for All of Us – from research groups at Baylor College of Medicine, the Broad Institute, Jackson Laboratory, Discovery Life Sciences, Harvard…
Meeting the threat of antimicrobial resistance with HiFi sequencing and artificial intelligence
After conducting a battery of technology comparisons, OpGen’s Ares Genetics has adopted PacBio HiFi microbial whole genome sequencing. The company believes the read length and high accuracy of HiFi…
Digest HiFi microbiome and metagenomics research with Publications at a Glance
Stay on top of important HiFi metagenomics research If you are interested in seeing how PacBio technology is making an impact in current metagenomics and microbiome research, our new…
The HiFi difference Christmas edition – Big genomes
This year, the scientific community has achieved many “firsts” – across genomes, transcriptomes, epigenomes, metagenomes, and more – with long and accurate HiFi sequencing. Another, seasonally timely, “first” was just…