Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Histogenetics Ramps Up HLA Typing with SMRT Sequencing
PacBio customer HistoGenetics was just awarded a major, multi-year contract to perform HLA typing on as many as thousands of samples per week using SMRT Sequencing. The company is a…
The Birth of a Symbiont: Epigenome Analysis Reveals Shifting Methylation Profile
A recent publication from scientists at the University of Florida and the University of Missouri used SMRT Sequencing to analyze epigenomic changes that occur when free-living bacteria associate with a…
Mitochondrial Genome Analysis Yields Novel Findings in Antiretroviral-Treated HIV Patients
Scientists from Yale University and Memorial Sloan Kettering Cancer Center used SMRT Sequencing to determine whether antiretroviral therapies were triggering mitochondrial genome mutations in HIV patients. The results were recently…
First Comprehensive View of Alternative Splicing in Sorghum Powered by SMRT Sequencing
A paper from scientists at Colorado State University and the National Center for Genome Resources provides an in-depth view of the transcriptome of sorghum, a crop that’s important for human…
In Chinese Genome Assembly, SMRT Sequencing Finds Novel Genes and Recovers Missing Sequence
A paper just out in Nature Communications reports the de novo genome assembly and transcriptome of a Chinese individual, generated from long-read SMRT Sequencing and other technologies. The effort revealed…
Iso-Seq Study Reveals More Complexity than Expected in Maize Transcriptome
In a new publication from Cold Spring Harbor Laboratory, scientists produced a dataset for what authors call “the single largest collection of [full-length] cDNAs available in maize” and significantly improved…
Data Release: Zika-Susceptible Aedes aegypti De Novo Genome Assembly
We are excited about the release of a new genome assembly for the mosquito Aedes aegypti, which we hope will aid scientists in studying vector-pathogen dynamics, including those of the…
East Coast UGM: SMRT Sequencing Data for Carnivorous Plants, Hummingbirds, Mammalian Methylation, Repeat Expansions, and More
Many thanks to the nearly 200 scientists who signed up for our East Coast User Group Meeting, and to the Institute for Genome Sciences for hosting us! The event was a…
SMRTest Microbe Grant Program:
Nominate Your Favorite Microbe Now!
We’re pleased to launch the latest opportunity to have your favorite microbe sequenced on a PacBio System. The SMRTest Microbe Grant Program, kicking off at this year’s American Society for…
Case Study: Institute for Genome Sciences Expands Long-Read Capabilities with Sequel System
An updated case study about the Genomics Resource Center (GRC) at the University of Maryland’s Institute for Genome Sciences (IGS) reports that SMRT Sequencing has become an integral tool for…
AACR Recap: Cancer Transcriptomes and a Moonshot Initiative
The PacBio team headed to New Orleans this past April to take in all the exciting new research presented at the American Association for Cancer Research Annual Meeting, show off…
Save the Spuds: UK Team Identifies Blight-Resistance Genes with SMRT Sequencing
Scientists from the UK published new work detailing important advances in protecting potatoes from the disease that caused the Irish potato famine in the 1800s. It’s not just of historical…
Discover New Insights into Human Genetic Variation at ESHG in Barcelona
The PacBio team is looking forward to joining 3,000 other scientists in Barcelona May 21-24 for the European Human Genetics Conference, better known as ESHG. Organized by the European Society…
Arizona Scientists Deploy BAC Expertise and SMRT Sequencing for Crop Genomes
At the University of Arizona, a leading genomics research facility benefits from decades of BAC-based sequencing expertise, original studies of crop genomes, and a unique emphasis on high molecular weight…
From Seabass to Salmon:
Swimming in High-Quality Genomes
A global collaboration of researchers has produced what is likely the most contiguous assembly of a fish genome to date. “Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence…