Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Reference Genomes Should Reflect Population Diversity: An Interview with Valerie Schneider
In a recent Mendelspod interview, host Theral Timpson talked with Valerie Schneider of the National Center for Biotechnology Information about the work of the Genome Reference Consortium (GRC) to bring…
G10K & B10K Initiatives to Generate Thousands of High-Quality Vertebrate Genomes to Aid Conservation Efforts
UPDATED September 14, 2018 The expanded G10K project, The Vertebrate Genome Project, released its first batch of 15 high-quality assemblies. ORIGINAL POST October 25, 2016 We’re excited to announce that…
Live Video: Discovering and Targeting Causative Variation Underlying Human Genetic Disease Using SMRT Sequencing
Identifying Structural Variants in NA12878 from Low-Fold Coverage Sequencing on the PacBio Sequel System
Recent de novo assemblies of individual human genomes have uncovered thousands of structural variants, many of which are accessible only with PacBio long reads [1-3]. Personal Genome PacBio Coverage Deletions…
ASHG 2016: Tune into SMRT Sequencing Presentations in Vancouver
We’re here in rainy, but beautiful Vancouver for the American Society of Human Genetics. ASHG 2016 promises to be every bit as fascinating as always, with great speakers, excellent sessions, and thought-provoking…
New FALCON Tools Enable Diploid Assemblies from SMRT Sequencing Data
In a Nature Methods paper released today, scientists describe the new bioinformatics tools to produce diploid genome assemblies from SMRT Sequencing reads. FALCON (Fast ALignment and CONsensus for assembly) and…
Diploid sssembly of Korean genome reveals population-specific variation and novel sequence
In a paper published today in Nature, scientists from Seoul National University, Macrogen, and other institutions present the de novo genome assembly for a Korean individual. The effort used SMRT…
West Coast User Group Meeting Recap: SMRT Sequencing for Goats, Grapes, Personalized Medicine & More
More than 150 SMRT Sequencing users gathered at Stanford University for our annual West Coast User Meeting & workshops earlier this month. Many thanks to all the scientists who attended…
Sequel System Data Release: Arabidopsis Dataset and Genome Assembly
Today we are pleased to release the first Arabidopsis thaliana (Ler-0) dataset and de novo genome assembly generated with the Sequel System, using two SMRT Cells and 12 hours of…
UPDATED Data Release: Comprehensive Alzheimer Brain Isoform Sequencing (Iso-Seq) Dataset
NOTE: This blog was updated with the latest data from the Sequel II System on March 9, 2020. Alzheimer’s disease (AD) is a devastating neurodegenerative disease that affects ~44 million…
Avian Celebrity: Kākāpō Genomes Make Headlines
A recent cover story in New Zealand Geographic vividly details the efforts to sequence not just the kākāpō genome, but the genomes of every single living kākāpō. If you missed…
Network with the SMRT Sequencing Community at Our Upcoming Events
We’re lucky to have such a vibrant community of SMRT Sequencing users, and there’s nothing better than getting them together to share tips, exchange ideas, and develop new applications. These…
Scientists Turn to SMRT Sequencing to Decode Chardonnay Genome
A case study produced by QRIScloud, an Australia-based cloud computing service, offers interesting insight into a recent project that is using SMRT Sequencing to generate a reference-quality de novo genome…
Precision Medicine Review Highlights Need for Accuracy & Comprehensiveness in Genome Sequencing
Stanford’s Euan Ashley wrote a terrific review about the clinical use of genome sequencing for Nature Reviews Genetics. “Towards Precision Medicine” is well worth a read, covering topics from the…
SMRT Sequencing Accurately Detects Gene Copy Numbers in Complex Maize Genome
Scientists from Rutgers University and the University of California, Davis, used SMRT Sequencing to study structural variation in maize. They found that this approach delivered more complete information at lower…