Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
With chromosome-scale resolution, draft durian genome explains smelly fruit
Scientists in Singapore, Hong Kong, and Malaysia recently reported the high-quality draft genome assembly of Durio zibethinus, a type of durian fruit commonly eaten in southeast Asia. The team used…
Iso-Seq analysis of polyploid cotton yields important discoveries for fiber breeding
Scientists at Huazhong Agricultural University in China and collaborating institutions recently published results of an Iso-Seq analysis of allotetraploid cotton. The team’s findings are expected to be particularly useful for…
ASHG 2017 Day 4: CRISPR/Cas9 Targeting and Structural Variant Calling CoLabs
A new program at ASHG this year came from the CoLaboratories, or educational theaters featuring 30-minute talks on a variety of clinical, laboratory, and data analysis topics. We were honored…
ASHG Day 2: Population and clinical genetics, plus a SMRT sequencing roadmap
The PacBio team hosted a luncheon workshop at ASHG yesterday titled “Population and Clinical Genetics Studies Using Long-read SMRT Sequencing.” Thanks to all the conference attendees who took time out…
ASHG 2017 Day 1: Structural variation, reference genomes, and more diversity
The annual meeting of the American Society of Human Genetics kicked off with a splash yesterday in Orlando, Fla. The PacBio team was thrilled that the opening talks in the…
HGSV Consortium study identifies sevenfold increase in structural variation
UPDATE (April 16, 2019): The paper has now been published in Nature Communications. ORIGINAL POST (October 12, 2017): The Human Genome Structural Variation Consortium, a successor to the 1000 Genomes…
Automated de novo assembly pipeline now available in Bluebee Cloud platform
Good news for cloud-loving PacBio users: genomics analysis service Bluebee has now implemented HGAP4 for de novo assembly of SMRT Sequencing data. It creates a fully automated, end-to-end assembly pipeline…
Sequel system boosts coverage, provides 40-fold cost reduction for amplicon sequencing
UPDATED March 27, 2018 This paper is now available at BMC Genomics. ORIGINAL POST October 5, 2017 A new preprint from scientists at the University of Guelph in Canada and the…
Raising Awareness for Ataxia & Progress Toward Understanding of the Disease Mechanism
Today is International Ataxia Awareness Day (IAAD), and we’re proud to be participating in this worthy cause. Ataxia is a group of rare, degenerative neurological diseases with a number of…
Data and Software Release: Target Capture and SMRT Sequencing for Alzheimer’s Disease Genes
We’re pleased to release a new data set along with an allele phasing GitHub software workflow for those interested in exploring SMRT Sequencing data from an Alzheimer’s disease candidate gene…
New Diploid Avian Reference Genomes to Establish Quality Standards for G10K, B10K
A new publication from scientists at The Rockefeller University and PacBio presents reference-grade, phased diploid genome assemblies for two important avian models for vocal learning, Anna’s hummingbird and zebra finch….
New Insights in Soil Ecology: SMRT Sequencing Powers Genome Assembly of Parthenogenetic Arthropod
In a recent BMC Genomics paper, scientists in the Netherlands report a high-quality genome assembly for Folsomia candida, a soil-dwelling arthropod. The organism, which is known for reproducing parthenogenetically (and…
At PMLS Meeting, a Focus on Boosting Genomic Representation of Ethnic Diversity
A panel session at the recent Precision Medicine Leaders Summit, held in San Diego last month, offered great perspectives on the need to better represent global ethnic diversity in order…
CRISPR/Cas9 and SMRT Sequencing Yield New Phenotype Association for SCA10 Repeat Expansion Disorder
A compelling new paper from scientists at the Parkinson’s Institute and Clinical Center, Houston Methodist Research Institute, and several other organizations demonstrates the importance of fully sequencing repeat expansion regions…
Medical-Grade Psychotropic May Be Feasible Thanks to New Genomics Study
A recent paper in the journal Angewandte Chemie describes using SMRT Sequencing to characterize biosynthesis of a psychotropic product in Psilocybe carpophores, better known as magic mushrooms. Scientists from the Hans…