What’s next
at PacBio?
Explore the innovations shaping the future of genomics
Built for what’s now and
prepared for what’s next
PacBio is advancing every layer of genomic sequencing to meet the challenges of tomorrow. If you’re a scientist pushing the edge of discovery or enabling scalable solutions in the clinic, here is where to find an inside look at what’s coming next.
From novel SMRT Cell designs to powerful new analysis tools, we’re opening the door to more accuracy, more access, and more possibilities.
Sign up for the SPRQ-Nx beta
Get access to Revio SPRQ-Nx multi-use SMRT Cells and chemistry to experience HiFi at a brand new price.
Reagents have shipped to initial beta sites. Sign up to learn more and be considered for the program when it expands in 2026.
Trouble loading the form? Register here.
SMRT Cells power PacBio sequencing.
Each chip holds millions of zero-mode waveguides (ZMWs) where a polymerase is observed sequencing DNA in real time. Advances in SMRT Cell density—from 75K ZMWs in 2011 to 25M on Revio—have fueled dramatic gains in throughput and cost efficiency. What’s next: even higher density, greater flexibility across applications, and multi-use designs to reduce costs and waste.
Multi-use SMRT Cells
Capture multiple sequencing movies on a single consumable. That means more data per SMRT Cell, lower costs, and less waste.
Sign up for beta access ->
Higher density SMRT Cells
25M ZMWs raised the bar. The next generation will go further, leveraging lessons from the 1M, 8M, and 25M designs to deliver even more yield, higher accuracy, and greater consistency.
See how to scale on the Revio system ->
300mm wafers
Adopting advances in microchip manufacturing will deliver smaller features, larger lot sizes, and lower costs.
Chemistry that keeps up with discovery
Our chemistry roadmap is built to unleash the power of genomics. With a proven track record of chemistry improvements, we continue to unlock access to complex regions, difficult targets, and new frontiers in disease biology. From repeat expansions to low DNA input, here’s what to be excited about:
Updates to sequencing chemistry
New reagent formulations designed to support novel workflows and increase overall performance.
Explore the latest on the Revio system ->
Sharper tools for deeper insights
True discovery is only as powerful as the tools behind it. Our new and upcoming software releases are built to interpret your most complex data accurately, automatically, and at scale. These tools and powerful algorithms allow you to extract the most information from the rich data that is HiFi. Whether you’re looking for causative variants, exploring the function of newly discovered regions of the genome, or training Large Language Models (LLMs) to make deep connections, HiFi has you covered.
Paraphase
Paralog genotyping method that’s ideal for rare disease and pharmacogenomics.
Learn more about Paraphase ->
A glimpse at what’s next in hardware
We’re continuing to develop long-read sequencing systems that build on the power of our fundamental HiFi technologies, delivering a suite of platforms that will offer even more speed, scale, and accuracy, without compromise.
Research & development forecast
At this year’s PRISM conference, chief operating officer Mark Van Oene discussed the PacBio R&D roadmap and technical advances.
See the presentation ->
Enabling what’s next in clinical-grade genomics
For customers building pipelines and workflows for regulated environments, we’re investing in tools, features, and partnerships that help you get there faster, including products designed to help you bring HiFi to regulated environments. Here are some of the latest:
