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This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.

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Going to ASM? Register Now for the Microbial Epigenetics Workshop on May 18

If you’ll be heading to Denver for the American Society for Microbiology annual meeting on May 18-21, don’t miss the pre-conference workshop on whole-genome microbial epigenetics. New studies are continually…

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From In Sequence: Spotlight on PacBio Customers’ Data at AGBT 2013

A recent article from In Sequence highlights several of our customers and the great projects they’ve been working on with single molecule, real-time (SMRT®) sequencing. If you’re not a subscriber…

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AGBT Day 4 Highlights: SMRT Sequencing for De Novo Genome Assemblies

Even as attendees’ energy was waning from three marathon days at AGBT, spirits were still high as we gathered for the final day’s Genomic Technologies session on Saturday morning. This…

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AGBT Day 3 Highlights: Long-Read Sequence Data Makes a Difference for Human, Crop Studies

The third day of sessions has wrapped up at AGBT, and we’ve got one day left to go. It’s the last leg of the marathon! We’ve been having a great…

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AGBT Day 2 Highlight: Bovine Immune Response Characterized with PacBio Sequencing

We survived the second day of AGBT, and the conference is officially in full swing. After an intense day of sessions focused on clinical genomics, the evening took us back…

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AGBT Day 1 Highlights: Focus on Epigenetics

Years ago, “epigenetics” was largely synonymous with methylation — in particular, 5-methylcytosine, which could be analyzed through bisulfite sequencing. Today, technologies have advanced and so has our understanding of the…

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AGBT 2013: Meeting Preview & PacBio Activities

This week we are fortunate to be attending the annual Advances in Genome Biology & Technology (AGBT) meeting in Marco Island, FL. The conference is always jam-packed with top tier…

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Mendelspod Interview with Mike Hunkapiller, CEO of Pacific Biosciences

Mike Hunkapiller was interviewed for a podcast recently on Mendelspod. In it, Mike and Mendelspod host Theral Timpson chat about the current sequencing technology landscape, clinical applications of sequencing, and…

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SMRT Sequencing Offers First Look at Fragile X Syndrome Repeat Expansion Disorder Sequence

Scientists at the University of California, Davis, School of Medicine have used the PacBio® RS to sequence a previously “unsequenceable” region of highly repetitive DNA on the X chromosome, providing…

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PAG Highlights and Workshop Recording: Generating High-Quality Bacterial, Plant and Animal Genomes

It was great to visit sunny San Diego for the International Plant and Animal Genome meeting last month. We were impressed with the quality of talks and posters, and we…

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Genome Finishing Gets Easier with PacBio Software Update

Plus: Accuracy Boost, Integrated Full-Length cDNA Analysis and Barcoding Support We’re pleased to announce the release of a new software upgrade — SMRT® Analysis v1.4.0 — that achieves higher quality…

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SMRT Sequencing for Industrial Biotech Applications

A feature article in the December 2012 issue of Industrial Biotechnology reports on various case studies where scientists have used the unique capabilities of SMRT® Sequencing to make discoveries in…

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A Closer Look at Accuracy in PacBio Sequencing

By Jonas Korlach, Chief Scientific Officer Single Molecule, Real-Time (SMRT®) DNA sequencing achieves highly accurate sequencing results, exceeding 99.999% (Q50) accuracy, regardless of the DNA’s sequence context or GC content….

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SMRT sequencing selected by 100K Pathogen Genome Project to finish genomes

A recently announced partnership with the University of California, Davis (UC Davis) highlights the benefits of one of the key applications for Single Molecule, Real-Time (SMRT®) Sequencing: rapid and complete…

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Baylor Team Uses PacBio’s SMRT® Sequencing to Upgrade and Finish Draft Genomes

Scientists at the Human Genome Sequencing Center at Baylor College of Medicine recently published a paper demonstrating the utility of PacBio’s long reads for upgrading and finishing draft genomes. “Mind…

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