Blog
October 18, 2016
ASHG 2016: Tune into SMRT Sequencing Presentations in Vancouver
We’re here in rainy, but beautiful Vancouver for the American Society of Human Genetics. ASHG 2016 promises to be every bit as fascinating as always, with great speakers, excellent sessions, and thought-provoking…
October 17, 2016
New FALCON Tools Enable Diploid Assemblies from SMRT Sequencing Data
In a Nature Methods paper released today, scientists describe the new bioinformatics tools to produce diploid genome assemblies from SMRT Sequencing reads. FALCON (Fast ALignment and CONsensus for assembly) and…
October 5, 2016
Diploid sssembly of Korean genome reveals population-specific variation and novel sequence
In a paper published today in Nature, scientists from Seoul National University, Macrogen, and other institutions present the de novo genome assembly for a Korean individual. The effort used SMRT…
September 29, 2016
West Coast User Group Meeting Recap: SMRT Sequencing for Goats, Grapes, Personalized Medicine & More
More than 150 SMRT Sequencing users gathered at Stanford University for our annual West Coast User Meeting & workshops earlier this month. Many thanks to all the scientists who attended…
September 27, 2016
Sequel System Data Release: Arabidopsis Dataset and Genome Assembly
Today we are pleased to release the first Arabidopsis thaliana (Ler-0) dataset and de novo genome assembly generated with the Sequel System, using two SMRT Cells and 12 hours of…
September 20, 2016
UPDATED Data Release: Comprehensive Alzheimer Brain Isoform Sequencing (Iso-Seq) Dataset
NOTE: This blog was updated with the latest data from the Sequel II System on March 9, 2020. Alzheimer’s disease (AD) is a devastating neurodegenerative disease that affects ~44 million…
September 6, 2016
Avian Celebrity: Kākāpō Genomes Make Headlines
A recent cover story in New Zealand Geographic vividly details the efforts to sequence not just the kākāpō genome, but the genomes of every single living kākāpō. If you missed…
September 1, 2016
Network with the SMRT Sequencing Community at Our Upcoming Events
We’re lucky to have such a vibrant community of SMRT Sequencing users, and there’s nothing better than getting them together to share tips, exchange ideas, and develop new applications. These…
August 26, 2016
Scientists Turn to SMRT Sequencing to Decode Chardonnay Genome
A case study produced by QRIScloud, an Australia-based cloud computing service, offers interesting insight into a recent project that is using SMRT Sequencing to generate a reference-quality de novo genome…
August 25, 2016
Precision Medicine Review Highlights Need for Accuracy & Comprehensiveness in Genome Sequencing
Stanford’s Euan Ashley wrote a terrific review about the clinical use of genome sequencing for Nature Reviews Genetics. “Towards Precision Medicine” is well worth a read, covering topics from the…
August 2, 2016
SMRT Sequencing Accurately Detects Gene Copy Numbers in Complex Maize Genome
Scientists from Rutgers University and the University of California, Davis, used SMRT Sequencing to study structural variation in maize. They found that this approach delivered more complete information at lower…
August 1, 2016
Histogenetics Ramps Up HLA Typing with SMRT Sequencing
PacBio customer HistoGenetics was just awarded a major, multi-year contract to perform HLA typing on as many as thousands of samples per week using SMRT Sequencing. The company is a…
July 28, 2016
The Birth of a Symbiont: Epigenome Analysis Reveals Shifting Methylation Profile
A recent publication from scientists at the University of Florida and the University of Missouri used SMRT Sequencing to analyze epigenomic changes that occur when free-living bacteria associate with a…
July 26, 2016
Mitochondrial Genome Analysis Yields Novel Findings in Antiretroviral-Treated HIV Patients
Scientists from Yale University and Memorial Sloan Kettering Cancer Center used SMRT Sequencing to determine whether antiretroviral therapies were triggering mitochondrial genome mutations in HIV patients. The results were recently…
July 11, 2016
First Comprehensive View of Alternative Splicing in Sorghum Powered by SMRT Sequencing
A paper from scientists at Colorado State University and the National Center for Genome Resources provides an in-depth view of the transcriptome of sorghum, a crop that’s important for human…