Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
HiFi sequencing uncovers the secret to aging gracefully in Earth’s oldest living organisms
If you’re looking for good advice on how to live a long and healthy life, you might ask someone who’s been around the block a few times. Or, in…
Cancer research gains a powerful new tool as Ampli-Fi makes HiFi sequencing possible for FFPE-preserved samples
Cancer research depends on the details we can actually see. And, until now, FFPE samples have not been compatible with long-read sequencing. That’s changing. This year at AACR, we…
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Selected publications from April 2025
This month’s April 2025 roundup features new research using PacBio HiFi sequencing to investigate unresolved questions in human health, evolution, and agriculture. From rethinking the genetic cause of a…
Customer success story:
How Berry Genomics is transforming complex single-gene disorder assays with HiFi sequencing
As one of China’s most prominent clinical genomics companies, Berry Genomics has a sharp focus on the prevention of genetic birth defects. Their team is constantly on the search…
Celebrating DNA Day and the long-read sequencing tools moving genomics forward
At PacBio, we’re celebrating DNA Day with excitement and appreciation—not just for what DNA is, but for how far we’ve come in decoding it. Each year on April 25,…
Customer success story:
How SPRQ chemistry boosts data output across continents at Signios Biosciences
What happens when one of the world’s top genomics service providers gets their hands on cutting-edge chemistry? Big things. At Signios Biosciences, innovation is the engine that drives powerful…
DNA extraction tips and best practices for HiFi sequencing
DNA extraction is the first step of any sequencing project. It’s often considered the easiest part of the workflow, compared to the more complicated steps of library prep, sequencing,…
Customer success story: The University of Bern takes long-read sequencing to the next level with SPRQ chemistry
The new SPRQ chemistry for the Revio system is making high-quality long-read sequencing more efficient than ever—delivering more data from less input without compromising accuracy or cost efficiency. But…
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Selected publications from March 2025
This month’s publications show how PacBio HiFi sequencing is being used to address complex problems in clinical genetics, brain research, and crop development. The March 2025 edition of our…
Inspiring the next generation of scientists: How multidisciplinary science powers PacBio technology
PacBio is hitting the pavement this weekend for the Seq It Forward 5K + Fun Run, backing San Diego LabRats and hands-on STEM education. Science starts young, and this event…
2024 SMRT Conserve grant winners
At PacBio, we see genomics as a powerful way to help protect Earth’s biodiversity. Around the world, researchers are working to sequence tens of thousands of species, gaining insights…
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Selected publications from February 2025
HiFi sequencing continues to drive discoveries across research areas, from chromatin architecture to immune system diversity and gene therapy safety. In the February 2025 edition of Powered by PacBio,…
Rare Disease Month: Putting People First
As February comes to a close, we approach Rare Disease Day on February 28 and reflect on the purpose behind our work in rare disease research. At PacBio, our…
How HiFi sequencing is making a difference for rare disease research at Children’s Mercy
A rare disease can be an immense burden on patients and families, especially when it comes to childhood conditions. The path from symptoms to diagnosis to treatment is often…
How HiFi sequencing lays the groundwork for accelerating rare disease diagnostics in the clinic
In February we are observing Rare Disease Month, a time to shine a light on the experiences of rare disease patients and their families. At PacBio, we are committed…