Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
2025 Microbiome SMRT Grant Awardees
We are thrilled to announce the winners of the 2025 Microbiome SMRT Grant for HiFi shotgun metagenomics. This year’s program received hundreds of amazing proposals from researchers around the…
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Selected publications from August 2025
This month’s publication highlights show how HiFi sequencing is helping researchers tackle challenges across clinical genomics research. See how HiFi is helping researchers sequence ultra-low input cancer samples, profile…
Looking to make sense of your research? There’s HiFi for that
The coffee’s cold, your pipette tips are backordered, and someone just booked your favorite lab bench. Science can be full of small annoyances. We can’t solve them all, but…
Fast-track biopharma breakthroughs with HiFi long-read sequencing
In biopharmaceutical research and development, the path from discovery to approved therapy can be long and complex, requiring innovation at every step. Success depends on understanding biology at its…
Sequencing 101: How multiplexing with long-read sequencing makes genomic research faster, cheaper, and smarter
Sequencing is the backbone of modern genomics. It has evolved over time, and as platforms grow to be faster and more accurate, researchers are finding new ways to maximize…
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Selected publications from July 2025
In July 2025’s publication roundup we’re proud to show how HiFi sequencing is playing a major role in advancing our understanding of the human brain, and autism in particular….
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How Dr. Ibrahim Bitar is doubling his research impact while leading the future of European genomics from the Czech Republic
When it comes to microbial genomics, Dr. Ibrahim Bitar doesn’t back down from a challenge. As an Assistant Professor of Microbiology at Charles University in Prague, and CEO of…
Publication spotlight: How Kinnex long-read RNA sequencing wins out over Illumina for transcript-level quantification
Kinnex has been making a splash since the day it launched – showing up in talks, turning heads in RNA labs, and putting its use cases solidly in the…
How long-read sequencing uncovers hitchhikers of the genomic galaxy in parasitic fungi
In the sci-fi classic The Hitchhiker’s Guide to the Galaxy, interstellar explorers hitch rides aboard ships that take them on wild, unexpected journeys across the cosmos. In a new…
Sequencing 101: Software and bioinformatics powering long-read sequencing
Today’s genome sequencing is nothing short of transformative. But the technology’s true potential isn’t unlocked by chemistry alone, it’s the software that brings it to life. If sequencing is…
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Selected publications from June 2025
What a month for Iso-Seq and Kinnex. The June 2025 edition of Powered by PacBio puts the spotlight on a suite of standout studies that tap into the full…
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How Miami University is using long-read sequencing on the Vega system to train the next generation of scientists
At Miami University in Oxford, Ohio, genomics lives outside the lecture hall. It’s active, hands-on, and fully integrated into how students learn and how research gets done. At…
How HiFi sequencing with the Ampli-Fi protocol can transform newborn screening with dried blood samples
Thanks to SPRQ chemistry and the Ampli-Fi protocol, researchers are now unlocking whole genomes from one of the most notoriously tricky sample types: dried blood spots (DBS). Collected from…
Celebrating Father’s Day with new discoveries of the Y chromosome achieved with HiFi sequencing
With Father’s Day around the corner, we’re raising a glass in honor of the dads, granddads, and father figures who show up with heart, humor, and a helping hand….
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Selected publications from May 2025
This month’s May 2025 publication roundup showcases how researchers are using PacBio HiFi sequencing to generate deeper insight into persistent scientific challenges. From uncovering hidden HIV-1 reservoirs, to revealing…