Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
Meet the winners of the 2025 long-read low-pass SMRT Grant for plant and animal sciences
As we head into the holiday season, we are more excited than ever to share some good news by announcing the winners of the 2025 Long-read Low-pass SMRT Grant…
Beyond the Bench:
A series celebrating the people behind scientific progress
When the lights turn on in a genomics lab, the day is already in motion. Boxes of samples wait to be logged, barcodes are scanned, concentrations get double-checked and…
Sequencing 101: A long-read sequencing starter guide for every career stage
The challenges of bringing on new technology feel surprisingly similar regardless of career stage or field. Grad students, bioinformaticians, PIs, and professionals running core facilities all want to make…
Powered by PacBio:
Selected publications from November 2025
November’s standout publications show how PacBio technology is impacting advances in human genomics research. This month’s selection includes studies on accurate variant detection in paralogous genes, a new visualization…
How long-read sequencing informs the future of food from genome to table
Thanksgiving is almost here, and we’re filled with gratitude for the food on our tables and the science that helps make this possible. From the corn in a casserole…
Publication spotlight:
First major study from the HiFi Solves EMEA consortium showcases the potential clinical power of a HiFi genome
We just got back from the Molecular Pathology (AMP) conference in Boston, where the conversation around clinical research and translational genomics was in full motion. The field is moving…
How pairing EpiCypher’s Fiber-seq with HiFi sequencing delivers an all-in-one multiomic view
As genetics research evolves, scientists are recognizing that it’s not just the DNA sequence that matters, it’s how that DNA is packaged. The study of epigenetics, how chromatin structure…
Powered by PacBio:
Selected publications from October 2025
This month’s roundup showcases the diverse ways researchers are using PacBio technology to uncover new insights across population genomics, cancer research, neurodegenerative disease, and precision medicine. In the October…
Publication spotlight:
Capturing the full picture of genome editing with custom PureTarget panels
In genome editing, precision is the goal, but biology has a way of introducing variation of its own. Genetic mosaicism occurs when different genetic variants coexist within the same…
Customer success story:
How two University of Michigan cores use HiFi sequencing to cut costs, save time, and improve accuracy in transgenic models
At the University of Michigan, two cores on opposite sides of campus are working together to change what’s possible in genomics. Judith Meyers helps run the Advanced Genomics Core…
Landmark All of Us study demonstrates HiFi sequencing as the key to uncovering disease variants
This week PacBio is bringing our energy and innovation in human genomics to ASHG in Boston, and there’s no better time to learn about what we’ve been up to….
How HiFi sequencing achieves scalable microbial genomics without compromise
Microbes touch every part of our lives. They’re what make up the beneficial communities living in our guts and the pathogens that drive major public health crises. If you’re…
Powered by PacBio:
Selected publications from September 2025
This month’s publications show just how versatile HiFi sequencing has become. In September, studies ranged from building the most comprehensive map yet of human genomic imprinting, to evaluating clinical…
How PureTarget is modernizing research into carrier screening
As many as 7 in 10 people carry at least one pathogenic genetic variant, even if they have no family history of disease1. That means most couples could unknowingly…
The growing importance of carrier screening in genomics
Carrier screening is one of the most influential ways genetics is shaping the future of human health. By revealing inherited risks before they ever appear, carrier screening has changed…