Blog
This blog features voices from PacBio — and our partners and colleagues — discussing the latest research, publications, and updates about HiFi sequencing.
Blog
How HiFi metagenomic sequencing is powering AI-driven discovery with Basecamp Research
Basecamp Research’s recent selection of PacBio HiFi sequencing to support its Trillion Gene Atlas initiative highlights an important shift in biological AI: the future will not be shaped by…
2025 Immunology and Immunotherapy SMRT Grant winners announced
Accurately capturing immune diversity is critical to advancing our understanding of disease mechanisms and enabling the development of more precise and effective therapies. However, conventional immune profiling technologies lack…
Cancer genomics myths revisited: How advances in HiFi sequencing keep strengthening the evidence
In cancer genomics, assumptions have a short shelf life. Not long ago we published a blog series debunking several common myths about long-read sequencing. At the time, many of…
What a clearer view of epigenetics can mean for cancer research
Cancer is not driven by DNA sequence mutations alone. Chemical modifications layered onto DNA can reshape gene regulation without altering the underlying code, silencing tumor suppressors, activating oncogenes, and…
Beyond the Bench: Exploring the terrain of repeat expansion diseases with HiFi sequencing
We’ve loved sharing the Beyond the Bench series with audiences this year. So far, we’re hearing from viewers how much they value seeing the human side of genomics, and…
Rare disease month: Activating the community through hackathons
This rare disease month, we’ve explored the power of telling families’ stories and the impact of adopting HiFi sequencing in real-world settings. Each perspective is a valuable piece of…
Radboud UMC research highlights promise of HiFi long-read sequencing to match standards of care in rare disease genomics
When you work in rare disease, you recognize the pattern: Test. Wait. Repeat. For families, that loop is a stretch of time that includes birthdays, school years, and treatment…
Rare Disease Month: Taking a People-First approach in the global fight against rare disease
Rare diseases are often described in numbers. Prevalence rates. Case counts. Years to diagnosis. But for families living with rare disease, those numbers are only part of the story….
How SPRQ-Nx enables affordable long-read whole genome sequencing without added complexity
Long-read whole genome sequencing is starting to show up in places it rarely could before. With the introduction of SPRQ-Nx, HiFi sequencing has now become the most affordable long-read…
Beyond the Bench: Advancing cancer transcriptomics with HiFi long-read RNA sequencing
With the PacBio Beyond the Bench video series now live, we’re feeling the enthusiasm surrounding a personal look at scientists’ lives and the rituals that anchor their work. This…
Publication spotlight: HiFi sequencing enables haplotype-specific chromatin mapping from single cells using DAF-seq
Oftentimes in biology, the biggest advances come from new ways of measuring complex systems, rather than a single discovery in itself. This publication spotlight highlights a recent Nature Biotechnology…
2025 Epigenetics SMRT Grant Awardees
Epigenetics offers critical insight into how the genome is regulated beyond DNA sequence alone, shaping cellular identity, function, and disease. Along with our co-sponsor EpiCypher, we are excited to…
A year in review: HiFi in the Headline
It’s 2026 and there’s no better time than now to look back at 2025 and celebrate its meaningful impact in genomics. In 2025, PacBio focused on driving technical advances,…
Meet the winners of the 2025 long-read low-pass SMRT Grant for plant and animal sciences
As we head into the holiday season, we are more excited than ever to share some good news by announcing the winners of the 2025 Long-read Low-pass SMRT Grant…
Beyond the Bench:
A series celebrating the people behind scientific progress
When the lights turn on in a genomics lab, the day is already in motion. Boxes of samples wait to be logged, barcodes are scanned, concentrations get double-checked and…