July 7, 2019  |  

Variant tolerant read mapping using min-hashing

Authors: Quedenfeld, Jens and Rahmann, Sven

DNA read mapping is a ubiquitous task in bioinformatics, and many tools have been developed to solve the read mapping problem. However, there are two trends that are changing the landscape of readmapping: First, new sequencing technologies provide very long reads with high error rates (up to 15%). Second, many genetic variants in the population are known, so the reference genome is not considered as a single string over ACGT, but as a complex object containing these variants. Most existing read mappers do not handle these new circumstances appropriately.

Journal: ArXiv
Year: 2017

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