The methodology of Genome-Wide Association Screening (GWAS) has been applied for more than a decade. Translation to clinical utility has been limited, especially in Alzheimer's Disease (AD). It has become standard practice in the analyses of more than two dozen AD GWAS studies to exclude the apolipoprotein E (APOE) region because of its extraordinary statistical support, unique thus far in complex human diseases. New genes associated with AD are proposed frequently based on SNPs associated with odds ratio (OR) < 1.2. most of these snps are not located within the associated gene exons or introns but variable distances away. often pathologic hypotheses for genes presented, with little no experimental support. by eliminating analyses apoe-tomm40 linkage disequilibrium region, relationship and data several that co-located in ld region have been largely ignored. early negative interpretations limited interest understanding genetic derived from gwas, particularly regarding tomm40 gene. this commentary describes history problem(s) interpretation interrogation "apoe" provides insight into a metabolic mitochondrial basis etiology ad using both apoe genetics. copyright © 2016 authors. published elsevier inc. all rights reserved.
Journal: Alzheimer's & dementia
DOI: 10.1016/j.jalz.2016.03.015
Year: 2016