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Authors: Zhang, Xiaojun and Sun, Lina and Yuan, Jianbo and Sun, Yamin and Gao, Yi and Zhang, Libin and Li, Shihao and Dai, Hui and Hamel, Jean-François and Liu, Chengzhang and Yu, Yang and Liu, Shilin and Lin, Wenchao and Guo, Kaimin and Jin, Songjun and Xu, Peng and Storey, Kenneth B and Huan, Pin and Zhang, Tao and Zhou, Yi and Zhang, Jiquan and Lin, Chenggang and Li, Xiaoni and Xing, Lili and Huo, Da and Sun, Mingzhe and Wang, Lei and Mercier, Annie and Li, Fuhua and Yang, Hongsheng and Xiang, Jianhai

Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important sea cucumber, A. japonicus, generated using Illumina and PacBio platforms, to achieve an assembly of approximately 805 Mb (contig N50 of 190 Kb and scaffold N50 of 486 Kb), with 30,350 protein-coding genes and high continuity. We used this resource to explore key genetic mechanisms behind the unique biological characters of sea cucumbers. Phylogenetic and comparative genomic analyses revealed the presence of marker genes associated with notochord and gill slits, suggesting that these chordate features were present in ancestral echinoderms. The unique shape and weak mineralization of the sea cucumber adult body were also preliminarily explained by the contraction of biomineralization genes. Genome, transcriptome, and proteome analyses of organ regrowth after induced evisceration provided insight into the molecular underpinnings of visceral regeneration, including a specific tandem-duplicated prostatic secretory protein of 94 amino acids (PSP94)-like gene family and a significantly expanded fibrinogen-related protein (FREP) gene family. This high-quality genome resource will provide a useful framework for future research into biological processes and evolution in deuterostomes, including remarkable regenerative abilities that could have medical applications. Moreover, the multiomics data will be of prime value for commercial sea cucumber breeding programs.

Journal: PLoS biology
DOI: 10.1371/journal.pbio.2003790
Year: 2017

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