April 21, 2020  |  

Relocation of Tn2009 and characterization of an ABGRI3-2 from re-sequenced genome sequence of Acinetobacter baumannii MDR-ZJ06.

Authors: Hua, Xiaoting and Xu, Qingye and Zhou, Zhihui and Ji, Shujuan and Yu, Yunsong

Sir,Acinetobacter baumannii is becoming an important opportunistic Gram-negative pathogen and has shown extensive MDR to most first-line antibiotics in recent years. The acquisition of the MDR phenotype is a determining factor for the success of A. baumannii. For example, blaOXA-23is the most common acquired gene for car- bapenem resistance, and it is acquired via mobile element. Our previous studies identified six clones (clones A–F) of imipenem- resistant A. baumannii strains isolated from 16 cities in 2005 in China and clone C was the dominant clone in various cities.1 One isolate of clone C, MDR-ZJ06, which belonged to global clone 2, was sequenced by the 454 Genome Sequencer FLX system, Illumina sequencer and Sanger sequencing. The blaOXA-23 of MDR-ZJ06 was located in Tn2009, which was initially named as part of the analysis of MDR-ZJ06 and was mostly reported in isolates from China. In this study, we present the revised complete genome sequence of A. baumannii MDR-ZJ06, which is widespread in China. Materials and methods are available as Supplementary data at JAC Online. The sequence data for the revised genome of A. baumannii MDR-ZJ06 have been deposited in GenBank under the accession number CP001937.2.

Journal: The Journal of antimicrobial chemotherapy
DOI: 10.1093/jac/dky521
Year: 2019

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