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Authors: Tsuchimatsu, Takashi and Goubet, Pauline M and Gallina, Sophie and Holl, Anne-Catherine and Fobis-Loisy, Isabelle and Bergès, Hélène and Marande, William and Prat, Elisa and Meng, Dazhe and Long, Quan and Platzer, Alexander and Nordborg, Magnus and Vekemans, Xavier and Castric, Vincent

Although the transition to selfing in the model plant Arabidopsis thaliana involved the loss of the self-incompatibility (SI) system, it clearly did not occur due to the fixation of a single inactivating mutation at the locus determining the specificities of SI (the S-locus). At least three groups of divergent haplotypes (haplogroups), corresponding to ancient functional S-alleles, have been maintained at this locus, and extensive functional studies have shown that all three carry distinct inactivating mutations. However, the historical process of loss of SI is not well understood, in particular its relation with the last glaciation. Here, we took advantage of recently published genomic resequencing data in 1,083 Arabidopsis thaliana accessions that we combined with BAC sequencing to obtain polymorphism information for the whole S-locus region at a species-wide scale. The accessions differed by several major rearrangements including large deletions and interhaplogroup recombinations, forming a set of haplogroups that are widely distributed throughout the native range and largely overlap geographically. "Relict" A. thaliana accessions that directly derive from glacial refugia are polymorphic at the S-locus, suggesting that the three haplogroups were already present when glacial refugia from the last Ice Age became isolated. Interhaplogroup recombinant haplotypes were highly frequent, and detailed analysis of recombination breakpoints suggested multiple independent origins. These findings suggest that the complete loss of SI in A. thaliana involved independent self-compatible mutants that arose prior to the last Ice Age, and experienced further rearrangements during postglacial colonization.© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Journal: Molecular biology and evolution
DOI: 10.1093/molbev/msx122
Year: 2017

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