High-quality assembly of Dermatophagoides pteronyssinus genome and transcriptome reveals a wide range of novel allergens.

Authors: Liu, Xiao-Yu and Yang, Kevin Yi and Wang, Ming-Qiang and Kwok, Jamie Sui-Lam and Zeng, Xi and Yang, Zhiyuan and Xiao, Xiao-Jun and Lau, Carol Po-Ying and Li, Ying and Huang, Zhi-Ming and Ba, Jin-Ge and Yim, Aldrin Kay-Yuen and Ouyang, Chun-Yan and Ngai, Sai-Ming and Chan, Ting-Fung and Leung, Elaine Lai-Han and Liu, Liang and Liu, Zhi-Gang and Tsui, Stephen Kwok-Wing

House dust mites (HDM) are a predominant source of inhalant allergens that attribute to over 50% of worldwide allergy cases, while the full spectrum of HDM allergens remains unknown. Here we sequenced a high-quality genome of Dermatophagoides (D.) pteronyssinus to find known canonical allergens and allergen orthologs inferred from D. farinae genome.

Journal: Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2017.12.910
Year: 2018

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