July 7, 2019  |  

Genomic analyses reveal that partial sequence of an earlier pseudorabies virus in China is originated from a Bartha-vaccine-like strain.

Authors: Ye, Chao and Guo, Jin-Chao and Gao, Jia-Cong and Wang, Tong-Yun and Zhao, Kuan and Chang, Xiao-Bo and Wang, Qian and Peng, Jin-Mei and Tian, Zhi-Jun and Cai, Xue-Hui and Tong, Guang-Zhi and An, Tong-Qing

Pseudorabies virus (PRV), the causative agent of Aujeszky?s disease, has gained increased attention in China in recent years as a result of the outbreak of emergent pseudorabies. Several genomic and partial sequences are available for Chinese emergent and European-American strains of PRV, but limited sequence data exist for the earlier Chinese strains. In this study, we determined the complete genomic sequence of one earlier Chinese strain SC and one emergent strain HLJ8. Compared with other known sequences, we demonstrated that PRV strains from distinct geographical regions displayed divergent evolution. Additionally, we report for the first time, a recombination event between PRV strains, and show that strain SC is a recombinant of an endemic Chinese strain and a Bartha-vaccine-like strain. These results contribute to our understanding of PRV evolution. Copyright © 2016 Elsevier Inc. All rights reserved.

Journal: Virology
DOI: 10.1016/j.virol.2016.01.016
Year: 2016

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