September 22, 2019  |  

Full gene HLA class I sequences of 79 novel and 519 mostly uncommon alleles from a large United States registry population.

Authors: Lazaro, Ana and Hou, Lihua and Tu, Bin and Masaberg, Carly and Enriquez, Elizabeth and Gerfen, Jennifer and Kariyawasam, Kanthi and Persaud, Misti and Qin, Xihan and Simbulan, Dannah and Xiao, Yi and Xun, Lisa and Yang, Ruyan and Ng, Jennifer and Hurley, Carolyn K

HLA class I assignments were obtained at single genotype, G-level resolution from 98?855 volunteers for an unrelated donor registry in the United States. In spite of the diverse ancestry of the volunteers, over 99% of the assignments at each locus are common. Within this population, 52 novel alleles differing in exons 2 and 3 are identified and characterized. Previously reported alleles with incomplete sequences in the IPD-IMGT/HLA database (n?=?519) were selected for full gene sequencing and, from this sampling, another 27 novel alleles are described.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Journal: HLA
DOI: 10.1111/tan.13377
Year: 2018

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