September 22, 2019  |  

Emergence of XDR Escherichia coli carrying both blaNDM and mcr-1 genes in chickens at slaughter and the characterization of two novel blaNDM-bearing plasmids.

Authors: Lv, Luchao and Zeng, Zhenling and Song, Qianhua and Cao, Yuping and Wang, Jing and Li, Wei and Wen, Qiaoling and Zhang, Qianhui and Wan, Miao and Yang, Jun and Liu, Jian-Hua

The emergence and spread of carbapenem-resistant isolates, especially New Delhi MBL (NDM)-producing Enterobacteriaceae, has become a global concern. Although NDM-producing Enterobacteriaceae have been mostly observed in clinical cases, they have also been identified in food-producing animals and wildlife. Recently, XDR bacteria harbouring both blaNDMand mcr-1 genes were observed in isolates from animals, posing a potential threat to public health. However, reports on the coexistence of blaNDMand mcr-1 in bacteria isolated from animals at slaughter remains sporadic. Here, we report two Escherichia coli strains, SD133 and SD138, co-producing NDM and MCR-1, isolated from chickens at slaughter in July 2015 in China.

Journal: The Journal of antimicrobial chemotherapy
DOI: 10.1093/jac/dky176
Year: 2018

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