April 21, 2020  |  

Cytotoxic and Antibacterial Cervinomycins B1-4 from a Streptomyces Species.

Authors: Hu, Xiaowen and Hu, Xinxin and Hu, Xiaomin and Li, Shufen and Li, LinLi and Yu, Liyan and Liu, Hongyu and You, Xuefu and Wang, Zhen and Li, Li and Yang, Beibei and Jiang, Bingya and Wu, Linzhuan

AntiSMASH analysis of genome DNA of Streptomyces CPCC 204980, a soil isolate with potent antibacterial activity, revealed a gene cluster for polycyclic xanthones. A subsequent chemical study confirmed that the microorganism produced polycyclic xanthone cervinomycin A2 (1) and the new congeners cervinomycins B1-4 (2-5). The structures of 1-5 were determined by comprehensive analyses of MS and NMR data, which indicated that 2-5 featured a common dihydro-D ring in the polycyclic xanthone core moiety of their molecules. 2-5 are toxic to human cancer cells and active against Gram-positive bacteria.

Journal: Journal of natural products
DOI: 10.1021/acs.jnatprod.9b00198
Year: 2019

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