July 7, 2019  |  

Bacterial genetics: SMRT-seq reveals an epigenetic switch.

Authors: Attar, Naomi

Streptococcus pneumoniae uses genetic diversification as a strategy to achieve phenotypic plasticity. For example, DNA inversion of the hsdS genes of type I restriction-modification (R-M) systems determines whether S. pneumoniae forms opaque or transparent colonies, which have different colonization and virulence characteristics. Zhang and colleagues now use single-molecule, real-time sequencing (SMRT-seq) to show the allelic variation of hsdS that results from site-specific recombination forms part of an epigenetic switch.

Journal: Nature reviews. Microbiology
DOI: 10.1038/nrmicro.2016.122
Year: 2016

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