July 7, 2019  |  

Analysis of the genome sequence of the medicinal plant Salvia miltiorrhiza.

Authors: Xu, Haibin and Song, Jingyuan and Luo, Hongmei and Zhang, Yujun and Li, Qiushi and Zhu, Yingjie and Xu, Jiang and Li, Ying and Song, Chi and Wang, Bo and Sun, Wei and Shen, Guoan and Zhang, Xin and Qian, Jun and Ji, Aijia and Xu, Zhichao and Luo, Xiang and He, Liu and Li, Chuyuan and Sun, Chao and Yan, Haixia and Cui, Guanghong and Li, Xiwen and Li, Xian'en and Wei, Jianhe and Liu, Juyan and Wang, Yitao and Hayward, Alice and Nelson, David and Ning, Zemin and Peters, Reuben J and Qi, Xiaoquan and Chen, Shilin

Salvia miltiorrhiza Bunge (Danshen) is a medicinal plant of the Lamiaceae family, and its dried roots have long been used in traditional Chinese medicine with hydrophilic phenolic acids and tanshinones as pharmaceutically active components (Zhang et al., 2014; Xu et al., 2016). The first step of tanshinone biosynthesis is bicyclization of the general diterpene precursor (E,E,E)-geranylgeranyl diphosphate (GGPP) to copalyl diphosphate (CPP) by CPP synthases (CPSs), which is followed by a cyclization or rearrangement reaction catalyzed by kaurene synthase-like enzymes (KSL).

Journal: Molecular plant
DOI: 10.1016/j.molp.2016.03.010
Year: 2016

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