April 21, 2020  |  

A new variant of mcr-1 identified from an extended-spectrum ß lactamase-producing Escherichia coli.

Authors: Cui, Yushan and Quan, Jingjing and Liao, Weichao and Zhao, Dongdong and Jiang, Yan and Du, Xiaoxing and Zhao, Feng and Yu, Yunsong

Plasmid-mediated colistin resistance gene, mcr-1, has been widely reported almost all over the world. The product of the gene, MCR-1, is one of the members of the phosphoethanolamine transferase enzyme family, which can add phosphoethanolamine to lipid A, thus reducing affinity to polymyxins. Isolates carrying mcr-1 gene are often multidrug resistant (MDR), including co-production of MCR-1 and extended spectrum B lactamases (ESBLs) or carbapenemases, resulting in great clinical concerns.

Journal: Journal of global antimicrobial resistance
DOI: 10.1016/j.jgar.2019.04.009
Year: 2019

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