A case of decreased susceptibility to ceftriaxone in Neisseria gonorrhoeae in the absence of a mosaic penicillin-binding protein 2 (penA) allele.

Authors: Abrams, A Jeanine and Kirkcaldy, Robert D and Pettus, Kevin and Fox, Jan L and Kubin, Grace and Trees, David L

We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 µg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.

Journal: Sexually transmitted diseases
DOI: 10.1097/OLQ.0000000000000645
Year: 2017

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