Cancer genomics
A more complete understanding of cancer genomes, epigenomes, and transcriptomes
Cancer genomics solutions
In order to fulfill the promise of cancer precision medicine, a more complete understanding of cancer’s complex biology is needed. Highly accurate sequencing from PacBio allows researchers to uncover novel biomarkers, including structural variants, fusions, isoforms, and epigenetic changes for a truly multiomic view of cancer.
Long-read WGS for somatic variant detection + epigenetics
Structural variants (genomic differences ≥50 bp) and changes in methylation and chromatin accessibility play vital roles in tumor initiation, progression, and resistance. HiFi WGS enables simultaneous discovery of SVs and other somatic variants with direct detection of methylation and the ability to phase genetic and epigenetic changes into haplotypes.
Long-read RNA sequencing for isoform + fusion discovery
Cancer exhibits widespread RNA dysregulation beyond simple changes in gene expression. The Iso-seq method powered by Kinnex uncovers the full spectrum of alternative splicing and fusion events for a more complete view of the cancer transcriptome.
Highly accurate short-read sequencing for rare variant detection
The detection of rare somatic variants is crucial for enabling early cancer detection and MRD monitoring. Highly accurate SBB short-read sequencing allows researchers to achieve unprecedented sensitivity and specificity for detecting rare variants in liquid biopsy and beyond.
Sequencing technology that spans the breadth of cancer research applications
Brochure
Cancer genomics
Understanding the complexity of cancer biology requires multiomic tools that can accurately and comprehensively profile all types of somatic and germline variation. These include not only small variants like SNVs and indels, but also structural variants, fusions, isoforms, differential methylation and chromatin accessibility, and changes in repetitive elements. It is also critical to be able to detect rare somatic variants at low frequency, either in plasma or in the tumor itself, as these may indicate the emerging recurrence or subclonal drug resistance. Highly accurate long and short read sequencing technology from PacBio addresses these challenges, providing comprehensive characterization of the changes that lead to cancer and enabling discovery of a new generation of cancer biomarkers.
Reveal hidden biomarkers
HiFi sequencing for a truly multi-omic view of cancer
PacBio HiFi reads on our Revio and Vega systems are both long (up to 25 kb) and accurate (≥90% of bases at Q30+), while including direct detection of epigenetic modifications like methylation. This means that researchers can take a wholistic and multi-omic approach to understanding cancer biology with a single technology that can access complete cancer genomes, epigenomes, and transcriptomes
Cancer genomics research in action
Publication
A comprehensive long-read isoform analysis platform for breast cancer
Long-read RNA sequencing identifies novel biomarkers and drug targets in breast cancer.
Complex oncogene amplifications revealed
A detailed map of structural variations in breast cancer.
Long reads reveal differences in drug response
Learn how PacBio’s accurate long-read RNA sequencing provides true discovery power of cancer-related RNA isoforms and allows for the understanding of molecular mechanisms underlying cancer biology in this webinar.
LONG-READ SEQUENCING REVEALS MORE OF THE TUMOR TRANSCRIPTOME
Researchers are moving away from using only short-read sequencing, making new insights into the role of RNA dysregulation in tumor biology.
Explore
Did you know we have a comprehensive library of articles, reports, papers, and videos related to cancer research?
THIS IS YOUR MOMENT
PacBio sequencers empower you to better understand the complex biology of cancer.
Reveal novel isoforms, fusions, and structural variants with exceptional accuracy.